Breast cancer during pregnancy of Luminal A type overexpressed CXCL13

被引：0

作者：

Nozaki, Fumi ^{[1
]}

Nakanishi, Yoko ^{[1
]}

Tanino, Tomoyuki ^{[1
]}

Ochi, Tomohiro ^{[2
]}

In, Reika ^{[2
,3
]}

Kajiura, Yuka ^{[2
]}

Kida, Kumiko ^{[2
]}

Takei, Junko ^{[2
]}

Yoshida, Atsushi ^{[2
]}

Kanomata, Naoki ^{[4
]}

Kitano, Atsuko ^{[5
]}

Yamauchi, Hideko ^{[2
]}

Masuda, Shinobu ^{[1
]}

机构：

[1] Nihon Univ, Sch Med, Dept Pathol & Microbiol, Div Oncol Pathol, 30-1 Oyaguchikami Cho,Itabashi Ku, Tokyo 1738610, Japan

[2] St Lukes Int Hosp, Dept Breast Surg Oncol, Tokyo, Japan

[3] Mammaria Tsukiji, Tokyo, Japan

[4] St Lukes Int Hosp, Dept Pathol, Tokyo, Japan

[5] St Lukes Int Hosp, Dept Med Oncol, Tokyo, Japan

来源：

PATHOLOGY INTERNATIONAL | 2024年 / 74卷 / 10期

关键词：

breast cancer; breast cancer during pregnancy (PrBC); CXCL13; pregnancy; pregnancy-associated breast cancer (PABC); WOMEN; PROGNOSIS; DIAGNOSIS;

D O I：

10.1111/pin.13474

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Pregnancy-associated breast cancer has been increasing. In this study, we analyzed patients with breast cancer that occurred during pregnancy (PrBC) and compared their genetic profiles with those of patients with breast cancer that did not occur during pregnancy, within 1 year after childbirth nor during lactation (non-PrBC). We performed gene expression analyses of patients with PrBC and non-PrBC using microarrays and qRT-PCR. Microarray analysis showed that 355 genes were upregulated in the luminal-type PrBC group compared to those in the non-PrBC group. The C-X-C motif chemokine ligand 13 (CXCL13) gene was the most upregulated in the PrBC group compared to that in the non-PrBC group, especially in the luminal A-type (p = 0.016). This result was corroborated by the qRT-PCR analysis of microdissected cancer cells (p < 0.001). A negative correlation was observed between CXCL13 and estrogen receptor 1 (ESR1) mRNA expression levels in luminal A-type breast carcinoma (p < 0.001). Our results provide clues for a better understanding of breast cancer pathogenesis during pregnancy.

引用

页码：592 / 603

页数：12

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