Perioperative research into memory (PRiMe), part 2: Adult burns intensive care patients show altered structure and function of the default mode network

被引：0

作者：

O'Connor, Stuart A. J. ^{[1
,2
]}

Watson, Edward J. R. ^{[1
,2
,9
]}

Grech-Sollars, Matthew ^{[3
,4
]}

Finnegan, Mary E. ^{[5
,6
]}

Honeyfield, Lesley ^{[5
]}

Quest, Rebecca A. ^{[5
,6
]}

Waldman, Adam D. ^{[7
,8
]}

Vizcaychipi, Marcela P. ^{[1
,2
]}

机构：

[1] Chelsea & Westminster Hosp NHS Fdn Trust, Magill Dept Anaesthesia, London, England

[2] Imperial Coll London, Dept Acad Anaesthesia Pain & Intens Care Med APMIC, London, England

[3] UCL, Dept Comp Sci, London, England

[4] Univ Coll London Hosp NHS Fdn Trust, Natl Hosp Neurol & Neurosurg, Lysholm Dept Neuroradiol, London, England

[5] Imperial Coll Healthcare NHS Trust, Dept Imaging, London, England

[6] Imperial Coll London, Dept Bioengn, London, England

[7] Univ Edinburgh, Ctr Clin Brain Sci, Edinburgh, Scotland

[8] Imperial Coll London, Dept Brain Sci, London, England

[9] Chelsea & Westminster Hosp, Div Anaesthesia Pain Med & Intens Care, 369 Fulham Rd, London SW10 9NH, England

来源：

BURNS | 2024年 / 50卷 / 07期

关键词：

Cognitive impairment; Default mode network; Functional neuroimaging; Intensive care; Burns; Magnetic resonance imaging; MILD COGNITIVE IMPAIRMENT; TEMPOROPARIETAL JUNCTION; BRAIN; CONNECTIVITY; DYSFUNCTION; ATTENTION; SURVIVORS;

D O I：

10.1016/j.burns.2024.05.008

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Background: Long-term cognitive impairment (LTCI) is experienced by up to two thirds of patients discharged from burns intensive care units (BICUs), however little is known about its neurobiological basis. This study investigated if patients previously admitted to BICU showed structural and functional MRI changes of the Default Mode Network (DMN). Methods: Fifteen patients previously admitted to BICU with a significant burns injury, and 15 matched volunteers, underwent structural and functional MRI scans. Functional connectivity, fractional anisotropy and cortical thickness of the main DMN subdivisions (anterior DMN (aDMN), posterior DMN (pDMN) and right (rTPJ) and left (lTPJ) temporo-parietal junctions) were compared between patients and volunteers, with differences correlated against cognitive performance. Results: Functional connectivity between rTPJ and pDMN (t = 2.91, p = 0.011) and between rTPJ and lTPJ (t = 3.18, p = 0.008) was lower in patients compared to volunteers. Functional connectivity between rTPJ and pDMN correlated with cognitive performance (r(2) =0.33, p < 0.001). Mean fractional anisotropy of rTPJ (t = 2.70, p = 0.008) and lTPJ (T = 2.39, p = 0.015) was lower in patients but there was no difference in cortical thickness. Conclusions: Patients previously admitted to BICU show structural and functional disruption of the DMN. Since functional changes correlate with cognitive performance, this should direct further research into intensive-care-related cognitive impairment.

引用

页码：1908 / 1915

页数：8