Lennox-Gastaut syndrome (LGS) is a form of severe childhood epilepsy, with most children experiencing seizures before reaching the age of eight. Typically, patients have multiple types of seizures, making an accurate diagnosis challenging. While it can be secondary to other causes, often, it is idiopathic. Over time, children develop cognitive impairment, leading to intellectual disability. The mainstay of treatment and management is seizure control. However, management remains challenging due to the complexity of the syndrome, as it is associated with multiple seizure types, intellectual deterioration, and other psychiatric comorbidities. We present the case of a 19-year-old male diagnosed with LGS and treated with various available therapies, who demonstrated multiple breakthrough seizures, significant neurocognitive disabilities, and behavior challenges. Additionally, the patient displayed psychotic features of auditory hallucinations, aggression, and attempts at self-mutilation, a rare clinical presentation in LGS.
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Univ Paris Diderot, Sorbonne Paris Cite, INSERM UMR1141, F-75019 Paris, France
Hop Robert Debre, AP HP, Serv Neurol Pediat & Malad Metab, F-75019 Paris, FranceUniv Paris Diderot, Sorbonne Paris Cite, INSERM UMR1141, F-75019 Paris, France
Auvin, Stephane
Dozieres, Blandine
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Hop Robert Debre, AP HP, Serv Neurol Pediat & Malad Metab, F-75019 Paris, FranceUniv Paris Diderot, Sorbonne Paris Cite, INSERM UMR1141, F-75019 Paris, France
Dozieres, Blandine
Ilea, Adina
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Hop Robert Debre, AP HP, Serv Neurol Pediat & Malad Metab, F-75019 Paris, FranceUniv Paris Diderot, Sorbonne Paris Cite, INSERM UMR1141, F-75019 Paris, France
Ilea, Adina
Delanoe, Catherine
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Hop Robert Debre, AP HP, Serv Explorat Fonct, F-75019 Paris, FranceUniv Paris Diderot, Sorbonne Paris Cite, INSERM UMR1141, F-75019 Paris, France
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Konyang Univ, Coll Med, Dept Pediat, Taejon, South KoreaKonyang Univ, Coll Med, Dept Pediat, Taejon, South Korea
Kim, Hyo Jeong
Kim, Shin Hye
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Kwandong Univ, Coll Med, Dept Pediat, Goyang, South KoreaKonyang Univ, Coll Med, Dept Pediat, Taejon, South Korea
Kim, Shin Hye
Kang, Hoon-Chul
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Yonsei Univ, Coll Med, Epilepsy Res Inst, Div Pediatr Neurol,Pediat Epilepsy Clin,Severance, Seoul 120752, South KoreaKonyang Univ, Coll Med, Dept Pediat, Taejon, South Korea
Kang, Hoon-Chul
Lee, Joon Soo
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Yonsei Univ, Coll Med, Epilepsy Res Inst, Div Pediatr Neurol,Pediat Epilepsy Clin,Severance, Seoul 120752, South KoreaKonyang Univ, Coll Med, Dept Pediat, Taejon, South Korea
Lee, Joon Soo
Chung, Hee Jung
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Natl Hlth Insurance Corp Ilsan Hosp, Dept Pediat, Goyang, South KoreaKonyang Univ, Coll Med, Dept Pediat, Taejon, South Korea
机构:
Univ Paris Diderot, Sorbonne Paris Cite, INSERM UMR1141, F-75019 Paris, France
Hop Robert Debre, AP HP, Serv Neurol Pediat & Malad Metab, F-75019 Paris, FranceUniv Paris Diderot, Sorbonne Paris Cite, INSERM UMR1141, F-75019 Paris, France
Auvin, Stephane
Dozieres, Blandine
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h-index: 0
机构:
Hop Robert Debre, AP HP, Serv Neurol Pediat & Malad Metab, F-75019 Paris, FranceUniv Paris Diderot, Sorbonne Paris Cite, INSERM UMR1141, F-75019 Paris, France
Dozieres, Blandine
Ilea, Adina
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h-index: 0
机构:
Hop Robert Debre, AP HP, Serv Neurol Pediat & Malad Metab, F-75019 Paris, FranceUniv Paris Diderot, Sorbonne Paris Cite, INSERM UMR1141, F-75019 Paris, France
Ilea, Adina
Delanoe, Catherine
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h-index: 0
机构:
Hop Robert Debre, AP HP, Serv Explorat Fonct, F-75019 Paris, FranceUniv Paris Diderot, Sorbonne Paris Cite, INSERM UMR1141, F-75019 Paris, France
机构:
Konyang Univ, Coll Med, Dept Pediat, Taejon, South KoreaKonyang Univ, Coll Med, Dept Pediat, Taejon, South Korea
Kim, Hyo Jeong
Kim, Shin Hye
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h-index: 0
机构:
Kwandong Univ, Coll Med, Dept Pediat, Goyang, South KoreaKonyang Univ, Coll Med, Dept Pediat, Taejon, South Korea
Kim, Shin Hye
Kang, Hoon-Chul
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Coll Med, Epilepsy Res Inst, Div Pediatr Neurol,Pediat Epilepsy Clin,Severance, Seoul 120752, South KoreaKonyang Univ, Coll Med, Dept Pediat, Taejon, South Korea
Kang, Hoon-Chul
Lee, Joon Soo
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h-index: 0
机构:
Yonsei Univ, Coll Med, Epilepsy Res Inst, Div Pediatr Neurol,Pediat Epilepsy Clin,Severance, Seoul 120752, South KoreaKonyang Univ, Coll Med, Dept Pediat, Taejon, South Korea
Lee, Joon Soo
Chung, Hee Jung
论文数: 0引用数: 0
h-index: 0
机构:
Natl Hlth Insurance Corp Ilsan Hosp, Dept Pediat, Goyang, South KoreaKonyang Univ, Coll Med, Dept Pediat, Taejon, South Korea