Dual C(sp3)-H and C(sp2)-H Activation of 8-Methylquinoline N-Oxides: A Route to Access C7-H Bond

被引：1
|
作者：
Mandal, Santu [1 ]
Barman, Madhab [1 ]
Debnath, Bijoy [1 ]
Punniyamurthy, Tharmalingam [1 ]
机构：
[1] Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, India
来源：
ORGANIC LETTERS | 2024年 / 26卷 / 36期
关键词：
C-H ACTIVATION; QUINOLINE; SITE; FUNCTIONALIZATION; PD; QUINAZOLINE; DERIVATIVES; ALKYLATION;
D O I：
10.1021/acs.orglett.4c02584
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A Pd(II)-catalyzed regioselective dual C(sp(3))-H/C7(sp(2))-H activation and annulation of 8-methylquinoline N-oxides with maleimide has been accomplished. The use of N-oxide as a weak directing group under Pd(II)-complex catalysis activates the initial C(sp(3))-H and triggers a relayed, second C7(sp(2))-H activation. The dual C-H bond activation, [3 + 2]-annulation, facile introduction and removal of the directing group, substrate scope, and functional group diversity are the important practical features.
引用
收藏
页码：7560 / 7564
页数：5
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