The BCG vaccine, advantages, and disadvantages of introducing new generation vaccines against Mycobacterium tuberculosis

被引：0
作者：
Ari, Marzie Mahdizade [1 ]
Beig, Masoumeh [2 ]
Sholeh, Mohammad [2 ]
Khoshmirsafa, Majid [1 ]
机构：
[1] Iran Univ Med Sci, Sch Med, Dept Microbiol, Tehran, Iran
[2] Pasteur Inst Iran, Dept Bacteriol, Tehran, Iran
来源：
CLINICAL AND EXPERIMENTAL VACCINE RESEARCH | 2024年 / 13卷 / 03期
关键词：
Tuberculosis; Mycobacterium; Mycobacterium bovis; Subunit vaccines; Synthetic vaccines; T-CELL RESPONSES; FUSION ANTIGEN; IN-VIVO; PROTECTION; IMMUNITY; IMMUNIZATION; EFFICACY; IMMUNOGENICITY; ADENOVIRUS; INFECTION;
D O I：
10.7774/cevr.2024.13.3.184
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Tuberculosis (TB) is consistently ranked among the deadliest diseases worldwide, causing millions of deaths annually. Mycobacterium tuberculosis is the causative agent for this infection. Different antibiotics and vaccines have been discussed as potential treatments and prevention. Currently, there is only one licensed vaccine against TB, Bacillus Calmette-Gu & eacute;rin (BCG). Despite its protective efficacy against TB in children, BCG has failed to protect adults against pulmonary TB, lacks therapeutic value, and can cause complications in immunocompromised individuals. In this review, BCG, the most widely administered vaccine, is discussed, and the newest vaccines available in medicine are discussed. Based on the restrictions that prevent optimal BCG efficacy and the vaccines that are now being tested in various clinical studies, some criteria need to be considered in designing future vaccines.
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收藏
页码：184 / 201
页数：18
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