Comprehensive review of multidimensional biomarkers in the ShangHai At Risk for Psychosis (SHARP) program for early psychosis identification

被引：8

作者：

Zhang, TianHong ^{[1
]}

Xu, LiHua ^{[2
]}

Tang, XiaoChen ^{[2
]}

Wei, YanYan ^{[2
]}

Hu, YeGang ^{[2
]}

Cui, HuiRu ^{[2
]}

Tang, YingYing ^{[2
]}

Li, ChunBo ^{[2
]}

Wang, JiJun ^{[2
,3
,4
]}

机构：

[1] Shanghai Jiaotong Univ Sch Med, Shanghai Engn Res Ctr Intelligent Psychol Evaluat, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, Shanghai, Peoples R China

[2] Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, Shanghai Key Lab Psychot Disorders, Shanghai, Peoples R China

[3] Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techno, Shanghai, Peoples R China

[4] Shanghai Jiao Tong Univ, Inst Psychol & Behav Sci, Shanghai, Peoples R China

来源：

PSYCHIATRY AND CLINICAL NEUROSCIENCES REPORTS | 2023年 / 2卷 / 04期

基金：

中国国家自然科学基金;

关键词：

biomarkers; clinical high risk; prediction; psychosis; CLINICAL HIGH-RISK; ULTRA-HIGH RISK; FOLLOW-UP; CALCULATOR; PRODROME; SCHIZOPHRENIA; SAMPLE; CHINA;

D O I：

10.1002/pcn5.152

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Psychosis is recognized as one of the largest contributors to nonfatal health loss, and early identification can largely improve routine clinical activity by predicting the psychotic course and guiding treatment. Clinicians have used the clinical high-risk for psychosis (CHR) paradigm to better understand the risk factors that contribute to the onset of psychotic disorders. Clinical factors have been widely applied to calculate the individualized risks for conversion to psychosis 1-2 years later. However, there is still a dearth of valid biomarkers to predict psychosis. Biomarkers, in the context of this paper, refer to measurable biological indicators that can provide valuable information about the early identification of individuals at risk for psychosis. The aim of this paper is to critically review studies assessing CHR and suggest possible biomarkers for application of prediction. We summarized the studies on biomarkers derived from the findings of the ShangHai at Risk for Psychosis (SHARP) program, including those that are considered to have the most potential. This comprehensive review was conducted based on expert opinions within the SHARP research team, and the selection of studies and results presented in this paper reflects the collective expertise of the team in the field of early psychosis identification. The three dimensions with potential candidates include neuroimaging dimension of brain structure and function, electrophysiological dimension of event-related potentials (ERPs), and immune dimension of inflammatory cytokines and complement proteins, which proved to be useful in supporting the prediction of psychosis from the CHR state. We suggest that these three dimensions could be useful as risk biomarkers for treatment optimization. In the future, when available for the integration of multiple dimensions, clinicians may be able to obtain a comprehensive report with detailed information of psychosis risk and specific indications about preferred prevention.

引用

页数：8

共 45 条

[1] Abnormal Function in Dentate Nuclei Precedes the Onset of Psychosis: A Resting-State fMRI Study in High-Risk Individuals [J].

Anteraper, Sheeba Arnold ;

Guell, Xavier ;

Collin, Guusje ;

Qi, Zhenghan ;

Ren, Jingwen ;

Nair, Atira ;

Seidman, Larry J. ;

Keshavan, Matcheri S. ;

Zhang, Tianhong ;

Tang, Yingying ;

Li, Huijun ;

McCarley, Robert W. ;

Niznikiewicz, Margaret A. ;

Shenton, Martha E. ;

Stone, William S. ;

Wang, Jijun ;

Whitfield-Gabrieli, Susan .

SCHIZOPHRENIA BULLETIN, 2021, 47 (05) :1421-1430

[2] Microglial Activity in People at Ultra High Risk of Psychosis and in Schizophrenia: An [11C]PBR28 PET Brain Imaging Study [J].

Bloomfield, Peter S. ;

Selvaraj, Sudhakar ;

Veronese, Mattia ;

Rizzo, Gala ;

Bertoldo, Alessandra ;

Owen, David R. ;

Bloomfield, Michael A. P. ;

Bonoldi, Ilaria ;

Kalk, Nicola ;

Turkheimer, Federico ;

McGuire, Philip ;

de Paola, Vincenzo ;

Howes, Oliver D. .

AMERICAN JOURNAL OF PSYCHIATRY, 2016, 173 (01) :44-52

[3] An Individualized Risk Calculator for Research in Prodromal Psychosis [J].

Cannon, Tyrone D. ;

Yu, Changhong ;

Addington, Jean ;

Bearden, Carrie E. ;

Cadenhead, Kristin S. ;

Cornblatt, Barbara A. ;

Heinssen, Robert ;

Jeffries, Clark D. ;

Mathalon, Daniel H. ;

McGlashan, Thomas H. ;

Perkins, Diana O. ;

Seidman, Larry J. ;

Tsuang, Ming T. ;

Walker, Elaine F. ;

Woods, Scott W. ;

Kattan, Michael W. .

AMERICAN JOURNAL OF PSYCHIATRY, 2016, 173 (10) :980-988

[4] Progressive Reduction in Cortical Thickness as Psychosis Develops: A Multisite Longitudinal Neuroimaging Study of Youth at Elevated Clinical Risk [J].

Cannon, Tyrone D. ;

Chung, Yoonho ;

He, George ;

Sun, Daqiang ;

Jacobson, Aron ;

van Erp, Theo G. M. ;

McEwen, Sarah ;

Addington, Jean ;

Bearden, Carrie E. ;

Cadenhead, Kristin ;

Cornblatt, Barbara ;

Mathalon, Daniel H. ;

McGlashan, Thomas ;

Perkins, Diana ;

Jeffries, Clark ;

Seidman, Larry J. ;

Tsuang, Ming ;

Walker, Elaine ;

Woods, Scott W. ;

Heinssen, Robert .

BIOLOGICAL PSYCHIATRY, 2015, 77 (02) :147-157

[5] Alterations in White Matter Evident Before the Onset of Psychosis [J].

Carettri, Francesco ;

Woolley, James B. ;

Bhattacharyya, Sagnik ;

Perez-Iglesias, Rocio ;

Poli, Paolo Fusar ;

Valmaggia, Lucia ;

Broome, Matthew R. ;

Bramon, Elvira ;

Johns, Louise ;

Giampietro, Vincent ;

Williams, Steve C. R. ;

Barker, Gareth J. ;

McGuire, Philip K. .

SCHIZOPHRENIA BULLETIN, 2012, 38 (06) :1170-1179

[6] A Severity-Based Clinical Staging Model for the Psychosis Prodrome: Longitudinal Findings From the New York Recognition and Prevention Program [J].

Carrion, Ricardo E. ;

Correll, Christoph U. ;

Auther, Andrea M. ;

Cornblatt, Barbara A. .

SCHIZOPHRENIA BULLETIN, 2017, 43 (01) :64-74

[7] Functional connectome organization predicts conversion to psychosis in clinical high-risk youth from the SHARP program [J].

Collin, Guusje ;

Seidman, Larry J. ;

Keshavan, Matcheri S. ;

Stone, William S. ;

Qi, Zhenghan ;

Zhang, Tianhong ;

Tang, Yingying ;

Li, Huijun ;

Anteraper, Sheeba Arnold ;

Niznikiewicz, Margaret A. ;

McCarley, Robert W. ;

Shenton, Martha E. ;

Wang, Jijun ;

Whitfield-Gabrieli, Susan .

MOLECULAR PSYCHIATRY, 2020, 25 (10) :2431-2440

[8] In vivo markers of inflammatory response in recent-onset schizophrenia: a combined study using [11C]DPA-713 PET and analysis of CSF and plasma [J].

Coughlin, J. M. ;

Wang, Y. ;

Ambinder, E. B. ;

Ward, R. E. ;

Minn, I. ;

Vranesic, M. ;

Kim, P. K. ;

Ford, C. N. ;

Higgs, C. ;

Hayes, L. N. ;

Schretlen, D. J. ;

Dannals, R. F. ;

Kassiou, M. ;

Sawa, A. ;

Pomper, M. G. .

TRANSLATIONAL PSYCHIATRY, 2016, 6 :1-8

[9] Baseline Cortical Thickness Reductions in Clinical High Risk for Psychosis: Brain Regions Associated with Conversion to Psychosis Versus Non-Conversion as Assessed at One-Year Follow-Up in the Shanghai-At-Risk-for-Psychosis (SHARP) Study [J].

del Re, Elisabetta C. ;

Stone, William S. ;

Bouix, Sylvain ;

Seitz, Johanna ;

Zeng, Victor ;

Guliano, Anthony ;

Somes, Nathaniel ;

Zhang, Tianhong ;

Reid, Benjamin ;

Lyall, Amanda ;

Lyons, Monica ;

Li, Huijun ;

Whitfield-Gabrieli, Susan ;

Keshavan, Matcheri ;

Seidman, Larry J. ;

McCarley, Robert W. ;

Wang, Jijun ;

Tang, Yingying ;

Shenton, Martha E. ;

Niznikiewicz, Margaret A. .

SCHIZOPHRENIA BULLETIN, 2021, 47 (02) :562-574

[10] Predicting Psychosis Meta-analysis of Transition Outcomes in Individuals at High Clinical Risk [J].

Fusar-Poli, Paolo ;

Bonoldi, Ilaria ;

Yung, Alison R. ;

Borgwardt, Stefan ;

Kempton, Matthew J. ;

Valmaggia, Lucia ;

Barale, Francesco ;

Caverzasi, Edgardo ;

McGuire, Philip .

ARCHIVES OF GENERAL PSYCHIATRY, 2012, 69 (03) :220-229

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