Pathogenicity and transmission of virulent Newcastle disease virus from the 2018-2019 California outbreak and related viruses in young and adult chickens

被引：28

作者：

Dimitrov, Kiril M. ^{[1
]}

Ferreira, Helena L. ^{[1
,2
]}

Pantin-Jackwood, Mary J. ^{[1
]}

Taylor, Tonya L. ^{[1
]}

Goraichuk, Iryna, V ^{[1
,3
]}

Crossley, Beate M. ^{[4
]}

Killian, Mary Lea ^{[5
]}

Bergeson, Nichole Hines ^{[5
]}

Torchetti, Mia Kim ^{[5
]}

Afonso, Claudio L. ^{[1
]}

Suarez, David L. ^{[1
]}

机构：

[1] ARS, Southeast Poultry Res Lab, US Natl Poultry Res Ctr, USDA, 934 Coll Stn Dr, Athens, GA 30605 USA

[2] Univ Sao Paulo, ZMV, FZEA, BR-13635900 Sao Paulo, Brazil

[3] Natl Sci Ctr, Inst Expt & Clin Vet Med, 83 Pushkinskaya St, UA-61023 Kharkov, Ukraine

[4] Univ Calif Davis, Calif Anim Hlth & Food Safety Lab Syst, Davis Branch, 620 West Hlth Sci Dr, Davis, CA 95620 USA

[5] USDA, Natl Vet Serv Labs, Vet Serv, 1920 Dayton Ave, Ames, IA 50010 USA

来源：

VIROLOGY | 2019年 / 531卷

关键词：

Newcastle disease virus; Avian paramyxovirus 1; Avian avulavirusl; California; Pathogenesis; Transmission; Shedding; Immunohistochemistry; Lesions; AVIAN PARAMYXOVIRUS SEROTYPE-1; SOUTHERN-CALIFORNIA; GENETIC DIVERSITY; UNITED-STATES; WILD BIRDS; STRAINS; PATHOGENESIS; GENOTYPE; IDENTIFICATION; VACCINATION;

D O I：

10.1016/j.virol.2019.03.010

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In May of 2018, virulent Newcastle disease virus was detected in sick, backyard, exhibition chickens in southern California. Since, the virus has affected 401 backyard and four commercial flocks, and one live bird market in California, and one backyard flock in Utah. The pathogenesis and transmission potential of this virus, along with two genetically related and widely studied viruses, chicken/California/2002 and chicken/Belize/2008, were evaluated in both 3-week- and 62-week-old chickens given a low, medium, or high challenge dose. All three viruses were highly virulent causing clinical signs, killing all the chickens in the medium and high dose groups, and efficiently transmitting to contacts. The three viruses also replicated in the reproductive tract of the adult hens. Virus shedding for all viruses was detected 24 hours after challenge, peaking with high titers at day 4 post challenge. Although not genetically identical, the studied isolates were shown to be phenotypically very similar, which allows the utilization of the available literature in the control of the current outbreak.

引用

页码：203 / 218

页数：16

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