The limelight of adipose-derived stem cells in the landscape of neural tissue engineering for peripheral nerve injury

被引：1

作者：

QingNing, Sun ^{[1
,2
]}

Ismail, Zul Izhar Mohd ^{[1
]}

Patar, Mohd Nor Azim Ab ^{[3
]}

Lazim, Norhafiza Mat ^{[4
]}

Hadie, Siti Nurma Hanim ^{[1
]}

Noor, Nor Farid Mohd ^{[5
]}

机构：

[1] Univ Sains Malaysia, Sch Med Sci, Dept Anat, Hlth Campus, Kubang Kerian 16150, Kelantan, Malaysia

[2] Zhengzhou Normal Univ, Sch Special Educ, Dept Rehabil, Zhengzhou 450044, Peoples R China

[3] Univ Sains Malaysia, Sch Med Sci, Dept Neurosci, Hlth Campus, Kubang Kerian 16150, Kelantan, Malaysia

[4] Univ Sains Malaysia, Sch Med Sci, Dept Otorhinolaryngol Head Neck Surg, Hlth Campus, Kubang Kerian 16150, Kelantan, Malaysia

[5] Univ Sultan Zainal Abidin, Fac Med, Med Campus, Kuala Terengganu 20400, Terengganu, Malaysia

来源：

TISSUE & CELL | 2024年 / 91卷

关键词：

Cell-based therapy; Neural tissue engineering; Nerve conduit; Biomaterials; Peripheral nerve regeneration; BONE-MARROW; IN-VIVO; SCHWANN-CELLS; REGENERATION; REPAIR; DIFFERENTIATION; TRANSPLANTATION; THERAPY; CONDUITS; SCAFFOLD;

D O I：

10.1016/j.tice.2024.102556

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Background and aims: Challenges in treating peripheral nerve injury include prolonged repair time and insufficient functional recovery. Stem cell therapy coupled with neural tissue engineering has been shown to induce nerve regeneration following peripheral nerve injury. Among these stem cells, adipose-derived stem cells (ADSCs) are preferred due to their accessibility, expansion, multidirectional differentiation, and production of essential nutrient factors for nerve growth. In recent years, ADSC-laden nerve guide conduit has been utilized to enhance the therapeutic effects of tissue-engineered nerve grafts. This review explores existing research that recognizes the roles played by ADSCs in inducing peripheral nerve regeneration following injury and summarizes the different methods of application of ADSC-laden nerve conduit in neural tissue engineering.

引用

页数：11

共 136 条

[41] Functional recoveries of sciatic nerve regeneration by combining chitosan-coated conduit and neurosphere cells induced from adipose-derived stem cells [J].