Electrochemical and DFT insights into 2-amino-4-(4-hydroxy-3-methoxyphenyl)-7-methyl-4H-chromene-3-carbonitrile: an innovative strategy for antibacterial activity and corrosion protection of carbon steel

被引:5
作者
Al Jahdaly, Badreah A. [1 ]
机构
[1] Umm Al Qura Univ, Fac Sci, Dept Chem, Mecca, Saudi Arabia
关键词
ADSORPTION BEHAVIOR; MILD-STEEL; INHIBITORS; DERIVATIVES; SURFACE; QUANTUM; COPPER;
D O I
10.1039/d4ra03785e
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
This study explored the potential of a newly synthesized derivative, 2-amino-4-(4-hydroxy-3-methoxyphenyl)-7-methyl-4H-chromene-3-carbonitrile (AHMCC), as a broad-spectrum antibacterial agent and a corrosion inhibitor for carbon steel (C.STL) in 0.5 M HCl solution. AHMCC demonstrated remarkable antibacterial efficacy against Gram-negative (Escherichia coli, Klebsiella pneumoniae) and Gram-positive (Bacillus subtilis, Staphylococcus aureus) bacteria, as evidenced by agar plate tests and cell viability assays. In the corrosion inhibition studies, AHMCC exhibited mixed-type inhibitor behavior as revealed by potentiodynamic polarization (PDP) measurements. The inhibition efficiency increased with rising AHMCC concentration, confirmed by a significant enhancement in charge transfer resistance (R-ct) observed in electrochemical impedance spectroscopy (EIS) analysis. Electrochemical frequency modulation (EFM) data with obtained CF2 and CF3 values further corroborated these findings. Langmuir isotherm modeling suggested AHMCC molecules followed a monolayer adsorption pattern on the C.STL surface. UV-visible spectroscopy indicated the formation of a protective layer through chemical interaction between AHMCC and the metal surface. Atomic force microscopy (AFM) provided visual confirmation of this protective film shielding the C.STL from the corrosive environment. Additionally, theoretical calculations supported the proposed adsorption mechanism of AHMCC molecules onto the C.STL surface.<br />
引用
收藏
页码:24039 / 24054
页数:16
相关论文
共 61 条
  • [1] Synthesis of tolyl guanidine as copper corrosion inhibitor with a complementary study on electrochemical and in silico evaluation
    Abdou, Moaz M.
    EL-Haddad, Mahmoud N.
    [J]. SCIENTIFIC REPORTS, 2022, 12 (01)
  • [2] Ahmed A, 2012, J PHARM PHARM SCI, V15, P52
  • [3] Structure-activity relationship (SAR) study and design strategies of nitrogen-containing heterocyclic moieties for their anticancer activities
    Akhtar, Jawaid
    Khan, Ahsan Ahmed
    Ali, Zulphikar
    Haider, Rafi
    Yar, M. Shahar
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 125 : 143 - 189
  • [4] Quinolones as prospective drugs: Their syntheses and biological applications
    Aly, Ashraf A.
    Ramadan, Mohamed
    Abuo-Rahma, Gamal El-Din A.
    Elshaier, Yaseen A. M. M.
    Elbastawesy, Mohammed A. I.
    Brown, Alan B.
    Braese, Stefan
    [J]. ADVANCES IN HETEROCYCLIC CHEMISTRY, VOL 135, 2021, 135 : 147 - 196
  • [5] Ansari K., 2017, J Assoc Arab Univ Basic Appl Sci, V22, P45
  • [6] Phenolic fraction of Ammi visnaga extract as environmentally friendly antioxidant and corrosion inhibitor for mild steel in acidic medium
    Aourabi, S.
    Driouch, M.
    Sfaira, M.
    Mahjoubi, F.
    Hammouti, B.
    Verma, Chandrabhan
    Ebenso, Eno E.
    Guo, L.
    [J]. JOURNAL OF MOLECULAR LIQUIDS, 2021, 323
  • [7] Synthesis, spectroscopic characterization and a comparative study of the corrosion inhibitive efficiency of an α-aminophosphonate and Schiff base derivatives: Experimental and theoretical investigations
    Benbouguerra, Khalissa
    Chafaa, Salah
    Chafai, Nadjib
    Mehri, Mouna
    Moumeni, Ouahiba
    Hellal, Abdelkader
    [J]. JOURNAL OF MOLECULAR STRUCTURE, 2018, 1157 : 165 - 176
  • [8] Bacterial Membrane Vesicles as Mediators of Microbe - Microbe and Microbe - Host Community Interactions
    Caruana, Julie C.
    Walper, Scott A.
    [J]. FRONTIERS IN MICROBIOLOGY, 2020, 11
  • [9] Study of corrosion behavior of API 5L X52 steel in sulfuric acid in the presence of ionic liquid 1-ethyl 3-methylimidazolium thiocyanate as corrosion inhibitor
    Corrales Luna, M.
    Tu Le Manh
    Cabrera Sierra, R.
    Medina Flores, J., V
    Lartundo Rojas, L.
    Arce Estrada, E. M.
    [J]. JOURNAL OF MOLECULAR LIQUIDS, 2019, 289
  • [10] Diaz MA., 2015, PHYTOCHEMICALS ISOLA, P141, DOI [DOI 10.5772/59819, 10.5772/59819]