Pathogenic mechanisms and latest therapeutic approaches for radiation-induced lung injury: A narrative review

被引：0
|
作者：
Chang, Sitong [1 ,2 ,3 ,4 ]
Lv, Jincai [1 ,2 ,5 ]
Wang, Xuanzhong [1 ,2 ,3 ,4 ]
Su, Jing [1 ,2 ,3 ,4 ]
Bian, Chenbin [1 ,2 ,3 ,4 ]
Zheng, Zhuangzhuang [1 ,2 ,3 ,4 ]
Yu, Huiyuan [1 ,2 ,3 ,4 ]
Bao, Jindian [1 ,2 ,3 ,4 ]
Xin, Ying [1 ,2 ,5 ]
Jiang, Xin [1 ,2 ,3 ,4 ]
机构：
[1] First Hosp Jilin Univ, Jilin Prov Key Lab Radiat Oncol & Therapy, Changchun, Peoples R China
[2] Jilin Univ, Coll Basic Med Sci, Changchun, Peoples R China
[3] First Hosp Jilin Univ, Dept Radiat Oncol, 1 Xinmin St, Changchun 130021, Peoples R China
[4] Jilin Univ, NHC Key Lab Radiobiol, Sch Publ Hlth, Changchun 130021, Peoples R China
[5] Jilin Univ, Key Lab Pathobiol, Minist Educ, 126 Xinmin St, Changchun 130021, Peoples R China
来源：
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2024年 / 202卷
关键词：
Radiation-induced lung injury; Therapy; Mesenchymal stem cells; Fibrosis; Pneumonitis; Radiotherapy; INDUCED PULMONARY-FIBROSIS; VOLUME HISTOGRAM ANALYSIS; MESENCHYMAL STEM-CELLS; TGF-BETA; CONCURRENT CHEMOTHERAPY; INDUCED PNEUMONITIS; OXIDATIVE STRESS; GROWTH-FACTOR; RISK-FACTORS; T-CELLS;
D O I：
10.1016/j.critrevonc.2024.104461
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The treatment of thoracic tumors with ionizing radiation can cause radiation-induced lung injury (RILI), which includes radiation pneumonitis and radiation-induced pulmonary fibrosis. Preventing RILI is crucial for controlling tumor growth and improving quality of life. However, the serious adverse effects of traditional RILI treatment methods remain a major obstacle, necessitating the development of novel treatment options that are both safe and effective. This review summarizes the molecular mechanisms of RILI and explores novel treatment options, including natural compounds, gene therapy, nanomaterials, and mesenchymal stem cells. These recent experimental approaches show potential as effective prevention and treatment options for RILI in clinical practice.
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页数：15
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