Children with sickle cell disease and severe COVID-19 presenting single nucleotide polymorphisms in innate immune response genes - A case report

被引：2
|
作者：
Pessoa, Natalia Lima [1 ,2 ]
Oliveira Diniz, Lilian Martins [3 ,4 ]
Andrade, Adriana de Souza [2 ]
Kroon, Erna Geessien [1 ]
Bentes, Aline Almeida [3 ,4 ]
Campos, Marco Antonio [2 ]
机构：
[1] Univ Fed Minas Gerais, Lab Virus, Inst Ciencias Biol, Dept Microbiol, Belo Horizonte, MG, Brazil
[2] Fundacao Oswaldo Cruz, Inst Rene Rachou, Imunol Doencas Virais, Belo Horizonte, MG, Brazil
[3] Univ Fed Minas Gerais, Dept Pediat, Fac Med, Belo Horizonte, MG, Brazil
[4] Fundacao Hosp Estado Minas Gerais, Hosp Joao Paulo II, Belo Horizonte, MG, Brazil
来源：
EJHAEM | 2022年 / 3卷 / 01期
关键词：
case report; COVID-19; innate immunity; sickle cell disease; single nucleotide polymorphisms; TIRAP; TLR-7;
D O I：
10.1002/jha2.325
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Here we report three clinical cases of children with sickle cell disease (SCD) and severe COVID-19 who evolved with complications during hospitalization or after discharge. They present single nucleotide polymorphisms in tlr-7 and tirap genes, identified from 37 patients under 16 years old hospitalized from September 2020 to May 2021 in the Hospital JoAo Paulo II, Belo Horizonte, Brazil. They presented significant complications of SCD as acute chest syndrome, splenic sequestration, and pain crisis during hospitalization or up to 2 months after SARS-CoV-2 infection. They all required transfusion of concentrated red blood cells and hospitalization in a reference hospital to care for children with SCD.
引用
收藏
页码：199 / 202
页数：4
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