Non-Faradaic Impedimetric Detection of Heavy Metal Ions via a Hybrid Nanoparticle-DNAzyme Biosensor

被引:0
作者
Panagopoulou, Chrysi [1 ]
Skotadis, Evangelos [1 ,2 ]
Aslanidis, Evangelos [1 ,3 ]
Tzourmana, Georgia [1 ]
Rapesi, Annita [1 ]
Tsioustas, Charalampos [1 ]
Kainourgiaki, Maria [1 ]
Kleitsiotis, Georgios [1 ]
Tsekenis, George [4 ]
Tsoukalas, Dimitrios [1 ]
机构
[1] Natl Tech Univ Athens, Dept Appl Phys, Athens 15780, Greece
[2] Univ West Attica, Dept Biomed Engn, Athens 12243, Greece
[3] Fdn Res & Technol Hellas FORTH, Inst Elect Struct & Laser IESL, Microelect Res Grp MRG, Iraklion 70013, Greece
[4] Biomed Res Fdn Acad Athens, Athens 11527, Greece
来源
BIOSENSORS-BASEL | 2024年 / 14卷 / 07期
关键词
heavy metal; biosensor; non-faradaic; impedance; EIS; DNAzymes; chromium; lead; nanoparticles; lab on chip; DNA; DROPLET; MICROELECTRODES; ENVIRONMENT; REMOVAL;
D O I
10.3390/bios14070321
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Due to rapid industrialization, novel water-quality monitoring techniques for the detection of highly toxic and hazardous heavy metal ions are essential. Herein, a hybrid noble nanoparticle/DNAzyme electrochemical biosensor is proposed for the simultaneous and label-free detection of Pb2+ and Cr3+ in aqueous solutions. The sensor is based on the combination of a two-dimensional naked-platinum nanoparticle film and DNAzymes, whose double-helix configuration disassembles into smaller fragments in the presence of target-specific heavy metal ions. The electrochemical behavior of the fabricated sensor was investigated with non-faradaic electrochemical impedance spectroscopy (EIS), resulting in the successful detection of Pb2+ and Cr3+ well below their maximum permitted levels in tap water. So far, there has been no report on the successful detection of heavy metal ions utilizing the non-faradaic electrochemical impedance spectroscopy technique based on advanced nanomaterials paired with DNAzymes. This is also one of the few reports on the successful detection of chromium (III) via a sensor incorporating DNAzymes.
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页数:21
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