Role of Exercise in the Management of Hepatic Encephalopathy: Experience From Animal and Human Studies

被引:11
作者
Aamann, Luise [1 ]
Tandon, Puneeta [2 ]
Bemeur, Chantal [3 ,4 ]
机构
[1] Aarhus Univ Hosp, Dept Hepatol & Gastroenterol, Aarhus, Denmark
[2] Univ Alberta, Div Gastroenterol, Dept Med, Edmonton, AB, Canada
[3] Univ Montreal, Fac Med, Dept Nutr, Montreal, PQ, Canada
[4] CRCHUM, Montreal, PQ, Canada
关键词
hepatic encephalopathy; exercise; liver disease; animal models; human; PHYSICAL-ACTIVITY; MUSCLE MASS; CIRRHOSIS; SARCOPENIA; INCREASES; MORTALITY;
D O I
10.1016/j.jceh.2018.07.006
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Sarcopenia and malnutrition are common features in patients with hepatic encephalopathy. Ammonia, a factor implicated in the pathophysiology of hepatic encephalopathy, may be cleared by the muscle via the enzyme glutamine synthetase when the liver function is impaired. Hence, optimizing muscle mass in patients suffering from hepatic encephalopathy is a potential strategy to decrease ammonia levels. Exercise could be an efficient therapeutic approach to optimize muscle mass and therefore potentially reduce the risk of hepatic encephalopathy in patients with chronic liver disease. This review reports the current evidence regarding exercise and hepatic encephalopathy from animal and human studies. After defining concepts such as frailty, sarcopenia, and malnutrition, the present knowledge regarding exercise as potential therapy in cirrhotic patients with or without hepatic encephalopathy is discussed. Recommendations and future aspects are also considered.
引用
收藏
页码:131 / 136
页数:6
相关论文
共 30 条
[1]   Resistance training improves muscle size and muscle strength in liver cirrhosis - a randomized controlled trial [J].
Aamann, L. ;
Dam, G. ;
Borre, M. ;
Drljevic-Nielsen, A. ;
Overgaard, K. ;
Andersen, H. ;
Vilstrup, H. ;
Aagaard, N. K. .
JOURNAL OF HEPATOLOGY, 2018, 68 :S79-S79
[2]   The Nutritional Management of Hepatic Encephalopathy in Patients With Cirrhosis: International Society for Hepatic Encephalopathy and Nitrogen Metabolism Consensus [J].
Amodio, Piero ;
Bemeur, Chantal ;
Butterworth, Roger ;
Cordoba, Juan ;
Kato, Akinobu ;
Montagnese, Sara ;
Uribe, Misael ;
Vilstrup, Hendrik ;
Morgan, Marsha Y. .
HEPATOLOGY, 2013, 58 (01) :325-336
[3]   Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation [J].
Bajaj, Jasmohan S. ;
Hylemon, Phillip B. ;
Ridlon, Jason M. ;
Heuman, Douglas M. ;
Daita, Kalyani ;
White, Melanie B. ;
Monteith, Pamela ;
Noble, Nicole A. ;
Sikaroodi, Masoumeh ;
Gillevet, Patrick M. .
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2012, 303 (06) :G675-G685
[4]   Nutrition in the Management of Cirrhosis and its Neurological Complications [J].
Bemeur, Chantal ;
Butterworth, Roger F. .
JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY, 2014, 4 (02) :141-150
[5]   Role of Nutrition in the Management of Hepatic Encephalopathy in End-Stage Liver Failure [J].
Bemeur, Chantal ;
Desjardins, Paul ;
Butterworth, Roger F. .
JOURNAL OF NUTRITION AND METABOLISM, 2010, 2010
[6]   Effects of an Intensive Lifestyle Intervention Program on Portal Hypertension in Patients With Cirrhosis and Obesity: The SportDiet Study [J].
Berzigotti, Annalisa ;
Albillos, Agustin ;
Villanueva, Candid ;
Genesca, Joan ;
Ardevol, Alba ;
Augustin, Salvador ;
Calleja, Jose Luis ;
Banares, Rafael ;
Garcia-Pagan, Juan Carlos ;
Mesonero, Francisco ;
Bosch, Jaime .
HEPATOLOGY, 2017, 65 (04) :1293-1305
[7]   Physical Activity and Liver Diseases [J].
Berzigotti, Annalisa ;
Saran, Uttara ;
Dufour, Jean-Francois .
HEPATOLOGY, 2016, 63 (03) :1026-1040
[8]   The bile duct ligated rat: A relevant model to study muscle mass loss in cirrhosis [J].
Bosoi, Cristina R. ;
Oliveira, Mariana M. ;
Ochoa-Sanchez, Rafael ;
Tremblay, Melanie ;
Ten Have, Gabriella A. ;
Deutz, Nicolaas E. ;
Rose, Christopher F. ;
Bemeur, Chantal .
METABOLIC BRAIN DISEASE, 2017, 32 (02) :513-518
[9]   Exercise and associated dietary extremes impact on gut microbial diversity [J].
Clarke, Siobhan F. ;
Murphy, Eileen F. ;
O'Sullivan, Orla ;
Lucey, Alice J. ;
Humphreys, Margaret ;
Hogan, Aileen ;
Hayes, Paula ;
O'Reilly, Maeve ;
Jeffery, Ian B. ;
Wood-Martin, Ruth ;
Kerins, David M. ;
Quigley, Eamonn ;
Ross, R. Paul ;
O'Toole, Paul W. ;
Molloy, Michael G. ;
Falvey, Eanna ;
Shanahan, Fergus ;
Cotter, Paul D. .
GUT, 2014, 63 (12) :1913-1920
[10]   Branched-chain amino acids and muscle ammonia detoxification in cirrhosis [J].
Dam, Gitte ;
Ott, Peter ;
Aagaard, Niels Kristian ;
Vilstrup, Hendrik .
METABOLIC BRAIN DISEASE, 2013, 28 (02) :217-220