Evaluation of teplizumab's efficacy and safety in treatment of type 1 diabetes mellitus: A systematic review and meta-analysis

被引:3
作者
Ma, Xiao-Lan [1 ]
Ge, Dan [1 ]
Hu, Xue-Jian [1 ]
机构
[1] Lanzhou Univ, Dept Endocrinol & Metab, Hosp 2, Lanzhou 730030, Gansu, Peoples R China
关键词
Type-1 diabetes mellitus; Teplizumab; Anti-CD3 monoclonal antibody; Insulin; Glycated haemoglobin A1c; C-peptide; C-PEPTIDE; THERAPIES;
D O I
10.4239/wjd.v15.i7.1615
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BACKGROUND Islets of Langerhans beta cells diminish in autoimmune type 1 diabetes mellitus (T1DM). Teplizumab, a humanized anti-CD3 monoclonal antibody, may help T1DM. Its long-term implications on clinical T1DM development, safety, and efficacy are unknown. AIM To assess the effectiveness and safety of teplizumab as a therapeutic intervention for individuals with T1DM. METHODS A systematic search was conducted using four electronic databases (PubMed, Embase, Scopus, and Cochrane Library) to select publications published in peer-reviewed journals written in English. The odds ratio (OR) and risk ratio (RR) were calculated, along with their 95%CI. We assessed heterogeneity using Cochrane Q and I2 statistics and the appropriate P value. RESULTS There were 8 randomized controlled trials (RCTs) in the current meta-analysis with a total of 1908 T1DM patients from diverse age cohorts, with 1361 patients receiving Teplizumab and 547 patients receiving a placebo. Teplizumab was found to have a substantial link with a decrease in insulin consumption, with an OR of 4.13 (95%CI: 1.72 to 9.90). Teplizumab is associated with an improved C-peptide response (OR 2.49; 95%CI: 1.62 to 3.81) and a significant change in Glycated haemoglobin A1c (HbA1c) levels in people with type 1 diabetes [OR 1.75 (95%CI: 1.03 to 2.98)], and it has a RR of 0.71 (95%CI: 0.53 to 0.95). CONCLUSION In type 1 diabetics, teplizumab decreased insulin consumption, improved C-peptide response, and significantly changed HbA1c levels with negligible side effects. Teplizumab appears to improve glycaemic control and diabetes management with good safety and efficacy.
引用
收藏
页数:13
相关论文
共 50 条
[31]   Effects of treatment in women with gestational diabetes mellitus: systematic review and meta-analysis [J].
Horvath, Karl ;
Koch, Klaus ;
Jeitler, Klaus ;
Matyas, Eva ;
Bender, Ralf ;
Bastian, Hilda ;
Lange, Stefan ;
Siebenhofer, Andrea .
BMJ-BRITISH MEDICAL JOURNAL, 2010, 340 :796
[32]   Clinical Effectiveness and Safety of Analog Glargine in Type 1 Diabetes: A Systematic Review and Meta-Analysis [J].
Marra, Lays P. ;
Araujo, Vania E. ;
Silva, Thales B. C. ;
Diniz, Leonardo M. ;
Guerra Junior, Augusto A. ;
Acurcio, Francisco A. ;
Godman, Brian ;
Alvares, Juliana .
DIABETES THERAPY, 2016, 7 (02) :241-258
[33]   Clinical Effectiveness and Safety of Analog Glargine in Type 1 Diabetes: A Systematic Review and Meta-Analysis [J].
Lays P. Marra ;
Vania E. Araújo ;
Thales B. C. Silva ;
Leonardo M. Diniz ;
Augusto A. Guerra Junior ;
Francisco A. Acurcio ;
Brian Godman ;
Juliana Álvares .
Diabetes Therapy, 2016, 7 :241-258
[34]   Stem cell transplantation for the treatment of patients with type 1 diabetes mellitus: A meta-analysis [J].
Gan, Jiadi ;
Wang, Yingjin ;
Zhou, Xiaodong .
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2018, 16 (06) :4479-4492
[35]   Effects of incretin-based therapies on β-cell function in type 1 diabetes mellitus: a systematic review and meta-analysis [J].
Wu, Yucheng ;
Lu, Yu ;
Yang, Shufang ;
Zhang, Qingqing .
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2021, 49 (12)
[36]   Therapeutic Effects of BCG Vaccination on Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials [J].
Chang, Yu-Chen ;
Lin, Chien-Ju ;
Hsiao, Yu-Hsuan ;
Chang, Yu-Han ;
Liu, Shu-Jung ;
Hsu, Hsin-Yin .
JOURNAL OF DIABETES RESEARCH, 2020, 2020
[37]   Probiotics, prebiotics, and synbiotics in type 1 diabetes mellitus: A systematic review and meta-analysis of clinical trials [J].
Moravejolahkami, Amir Reza ;
Shakibaei, Mehdi ;
Fairley, Andrea Mary ;
Sharma, Manoj .
DIABETES-METABOLISM RESEARCH AND REVIEWS, 2024, 40 (02)
[38]   Efficacy and Safety of Insulin Degludec/Insulin Aspart (IDegAsp) in Type 2 Diabetes: Systematic Review and Meta-Analysis [J].
Edina, Brenda C. ;
Tandaju, Jeremy R. ;
Wiyono, Lowilius .
CUREUS JOURNAL OF MEDICAL SCIENCE, 2022, 14 (06)
[39]   Efficacy and safety of acarbose combined with insulin in treatment of type 2 diabetes mellitus: a meta-analysis of randomized controlled trials [J].
Hu, Haiying ;
Zheng, Jia ;
Chen, Xian ;
Jiang, Diying ;
Sun, Xiaomeng ;
Qian, Yingying ;
Zhang, Yan ;
Chen, Jingsen .
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2017, 10 (11) :15071-15079
[40]   Liraglutide as Adjunct to Insulin Treatment in Patients with Type 1 Diabetes: A Systematic Review and Meta-analysis [J].
Dimitrios, Patoulias ;
Michael, Doumas ;
Vasilios, Kotsis ;
Konstantinos, Stavropoulos ;
Konstantinos, Imprialos ;
Ioanna, Zografou ;
Konstantinos, Petidis ;
Spyridon, Bakatselos ;
Asterios, Karagiannis .
CURRENT DIABETES REVIEWS, 2020, 16 (04) :313-326