Experimental Measurements of the Length of the Human Colon: A Systematic Review and Meta-Analysis

被引:0
|
作者
Alqarni, Faiz [1 ,2 ,3 ]
Akbar, Tejal [1 ,2 ]
Fatani, Hala [1 ,2 ]
Kumasaka, Soma [4 ,5 ]
Hoad, Caroline L. [2 ,6 ]
Spiller, Robin C. [1 ,2 ]
Taylor, Moira A. [2 ,7 ]
Marciani, Luca [1 ,2 ]
机构
[1] Univ Nottingham, Nottingham Digest Dis Ctr, Sch Med, Translat Med Sci, Nottingham NG7 2UH, England
[2] Nottingham Univ Hosp NHS Trust, Univ Nottingham, Natl Inst Hlth & Care Res NIHR, Nottingham Biomed Res Ctr, Nottingham NG7 2UH, England
[3] King Saud Med City, Minist Hlth, Riyadh 11196, Saudi Arabia
[4] Gunma Univ, Grad Sch Med, Dept Diagnost Radiol & Nucl Med, Maebashi 3718511, Japan
[5] Univ Nottingham, Sch Med, Radiol Sci, Nottingham NG7 2UH, England
[6] Univ Nottingham, Sir Peter Mansfield Imaging Ctr, Sch Phys & Astron, Nottingham NG7 2RD, England
[7] Univ Nottingham, Sch Life Sci, David Greenfield Human Physiol Unit, Nottingham NG7 2UH, England
关键词
colon length; large intestine length; large bowel morphology; colon measurements; colon anatomy; LARGE-INTESTINE; QUANTITATIVE ASSESSMENT; SIGMOID COLON; SURFACE-AREA; COLONOSCOPY; ANATOMY; SEGMENT; MORPHOLOGY; CHILDREN; TRANSIT;
D O I
10.3390/diagnostics14192190
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose: Knowledge of the length of the colon is relevant to understanding physiological and pathological function. It also has implications for diagnostic and clinical interventions, as well as for the design of delayed-release drug formulations and drug disposition modeling. Methods: Over the years, a range of different experimental methods have been employed to assess colon length. These methods vary from direct measurements on cadavers and during intraoperative procedures to measurements obtained from endoscopic and medical imaging techniques. However, no systematic review or meta-analysis of these findings has yet been carried out. In this systematic review, we identified 31 published experimental studies that measured the length of the human colon and/or its segments. Results: We synthesized the available data, comprising colon length measurements from 5741 adults and 337 children and young people, in a meta-analysis. The data contribute to our understanding of colon morphology and may have implications for clinical practice, particularly for colonoscopy and preoperative planning of surgical resections. Additionally, this review provides potential insights into anatomical correlates of functional diseases, such as constipation. Conclusions: This review highlights that non-invasive, non-destructive diagnostic imaging techniques, such as magnetic resonance imaging (MRI), can provide more physiologically relevant measurements of colon length. However, there is a need for more standardized measurement protocols and for additional pediatric data.
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页数:20
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