Genetic and Epigenetic Interactions Involved in Senescence of Stem Cells

被引:1
|
作者
Iordache, Florin [1 ,2 ]
Petcu, Adriana Cornelia Ionescu [1 ]
Alexandru, Diana Mihaela [3 ]
机构
[1] Univ Agron Sci & Vet Med, Fac Vet Med, Biochem Disciplines, Bucharest 050097, Romania
[2] Politehn Univ, Adv Res Ctr Innovat Mat Prod & Proc CAMPUS, Bucharest 060042, Romania
[3] Univ Agron Sci & Vet Med, Fac Vet Med, Pharmacol & Pharm Disciplines, Bucharest 050097, Romania
关键词
stem cells; epigenetics; methylation; acetylation; histone; cellular senescence; NAKED MOLE-RAT; CELLULAR SENESCENCE; OSTEOGENIC DIFFERENTIATION; SECRETORY PHENOTYPE; TUMOR SUPPRESSION; DNA METHYLATION; ANIMAL-MODELS; STRESS; CANCER; 5-METHYLCYTOSINE;
D O I
10.3390/ijms25179708
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cellular senescence is a permanent condition of cell cycle arrest caused by a progressive shortening of telomeres defined as replicative senescence. Stem cells may also undergo an accelerated senescence response known as premature senescence, distinct from telomere shortening, as a response to different stress agents. Various treatment protocols have been developed based on epigenetic changes in cells throughout senescence, using different drugs and antioxidants, senolytic vaccines, or the reprogramming of somatic senescent cells using Yamanaka factors. Even with all the recent advancements, it is still unknown how different epigenetic modifications interact with genetic profiles and how other factors such as microbiota physiological conditions, psychological states, and diet influence the interaction between genetic and epigenetic pathways. The aim of this review is to highlight the new epigenetic modifications that are involved in stem cell senescence. Here, we review recent senescence-related epigenetic alterations such as DNA methylation, chromatin remodeling, histone modification, RNA modification, and non-coding RNA regulation outlining new possible targets for the therapy of aging-related diseases. The advantages and disadvantages of the animal models used in the study of cellular senescence are also briefly presented.
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页数:29
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