A metal-quercetin-histidine co-coordinated nanoparticle enhances cancer photothermal therapy via reshaping immunosuppressive tumor microenvironment

被引:1
作者
Wang, Shaobo [1 ,2 ]
Yao, Shuncheng [2 ,3 ]
Hu, Quanhong [1 ,2 ]
Wang, Zhuo [2 ]
Zhao, Yunchao [2 ,4 ]
Li, Linlin [1 ,2 ,3 ]
机构
[1] Guangxi Univ, Guangxi Coll & Univ Key Lab Blue Energy & Syst Int, Inst Sci & Technol Carbon Peak & Neutral, Ctr Nanoenergy Res,Sch Phys Sci & Technol, Nanning 530004, Peoples R China
[2] Chinese Acad Sci, Beijing Inst Nanoenergy & Nanosyst, Ctr High Entropy Energy & Syst, Beijing Key Lab Micronano Energy & Sensor, Beijing 101400, Peoples R China
[3] Univ Chinese Acad Sci, Sch Nanosci & Engn, Beijing 100049, Peoples R China
[4] Shandong Agr Univ, Coll Chem & Mat Sci, Tai An 271018, Peoples R China
基金
中国国家自然科学基金;
关键词
Photothermal therapy; Quercetin; Amino acid; PD-L1; Immunotherapy;
D O I
10.1016/j.cej.2024.156027
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Photothermal therapy (PTT) relying on photothermal conversion agents (PCAs) to generate local hyperthermia and eliminate tumors is considered as a high-efficiency localized treatment method for cancer. However, PTT inadvertently exacerbates tumor immune evasion and recurrence, and leads to tumor metastasis through producing excessive free radicals and inflammatory responses at the tumor microenvironment (TME). Facing this challenge, here, we designed metal-quercetin-histidine co-coordinated nanoparticles (FQH NPs) as a multifunctional PCA with capacity of reversing immunosuppressive TME and activating the "cold" tumor to "hot". Through co-coordination guided band-ligand-to-metal charge transfer (LMCT), the self-assembled FQH NPs exhibit robust photothermal conversion capabilities, efficiently scavenge various ROS generated during PTT, and decrease excretion of pro-inflammatory factor interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha). Furthermore, FQH NPs remarkably decrease the expression of programmed death ligand 1 (PD-L1) on cancer cells, thereby increasing activation of T cells in tumors. Combining with the immunogenic cell death (ICD) effect during PTT, this immune-checkpoint inhibition effect conquers the "cold" orthotopic breast cancer, prevents liver/lung metastasis, and also inhibits the growth of distal tumors through immune memory effect. It offers perspectives and potential avenues for improving photothermal cancer therapy.
引用
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页数:12
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