Pancreatic Cancer: A Review of Risk Factors

被引:3
作者
Grigorescu, Raluca Roxana [1 ]
Husar-Sburlan, Ioana Alexandra [2 ]
Gheorghe, Cristian [3 ]
机构
[1] Carol Davila Univ Med & Pharm, Sfanta Maria Hosp, Gastroenterol Dept, Bucharest 020021, Romania
[2] Sfanta Maria Hosp, Gastroenterol Dept, Bucharest 011172, Romania
[3] Carol Davila Univ Med & Pharm, Fundeni Clin Inst, Ctr Digest Dis & Liver Transplantat, Bucharest 020021, Romania
来源
LIFE-BASEL | 2024年 / 14卷 / 08期
关键词
pancreatic cancer; risk factors; obesity; microbiota; diabetes; PAPILLARY MUCINOUS NEOPLASMS; RENIN-ANGIOTENSIN SYSTEM; ABO BLOOD-GROUP; IMPAIRED GLUCOSE-TOLERANCE; BRCA2 GERMLINE MUTATIONS; PEUTZ-JEGHERS-SYNDROME; LONG-TERM SURVIVAL; HEPATITIS-B-VIRUS; FACTOR-I RECEPTOR; VITAMIN-D STATUS;
D O I
10.3390/life14080980
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Pancreatic adenocarcinoma is one of the most lethal types of gastrointestinal cancer despite the latest medical advances. Its incidence has continuously increased in recent years in developed countries. The location of the pancreas can result in the initial symptoms of neoplasia being overlooked, which can lead to a delayed diagnosis and a subsequent reduction in the spectrum of available therapeutic options. The role of modifiable risk factors in pancreatic cancer has been extensively studied in recent years, with smoking and alcohol consumption identified as key contributors. However, the few screening programs that have been developed focus exclusively on genetic factors, without considering the potential impact of modifiable factors on disease occurrence. Thus, fully understanding and detecting the risk factors for pancreatic cancer represents an important step in the prevention and early diagnosis of this type of neoplasia. This review reports the available evidence on different risk factors and identifies the areas that could benefit the most from additional studies.
引用
收藏
页数:34
相关论文
共 50 条
  • [41] Risk factors for pancreatic cancer: underlying mechanisms and potential targets
    Pandol, Stephen J.
    FRONTIERS IN PHYSIOLOGY, 2014, 5
  • [42] Lifestyle, occupational, and reproductive factors in relation to pancreatic cancer risk
    Lo, An-Chi
    Soliman, Amr S.
    El-Ghawalby, Nabih
    Abdel-Wahab, Mohamed
    Fathy, Omar
    Khaled, Hussein M.
    Omar, Sherif
    Hamilton, Stanley R.
    Greenson, Joel K.
    Abbruzzese, James L.
    PANCREAS, 2007, 35 (02) : 120 - 129
  • [43] Identifying the risk factors for pancreatic fistula after laparoscopic pancreaticoduodenectomy in patients with pancreatic cancer
    Xu, Hang
    Meng, Qing-Cai
    Hua, Jie
    Wang, Wei
    WORLD JOURNAL OF GASTROINTESTINAL SURGERY, 2024, 16 (06):
  • [44] Risk Factors for Pancreatic Cancer in Patients with New-Onset Diabetes: A Systematic Review and Meta-Analysis
    Mellenthin, Claudia
    Balaban, Vasile Daniel
    Dugic, Ana
    Cullati, Stephane
    CANCERS, 2022, 14 (19)
  • [45] Tobacco and alcohol as risk factors for pancreatic cancer
    Korc, Murray
    Jeon, Christie Y.
    Edderkaoui, Mouad
    Pandol, Stephen J.
    Petrov, Maxim S.
    BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY, 2017, 31 (05) : 529 - 536
  • [46] Risk factors and early diagnosis of pancreatic cancer
    Lopez Serrano, Antonio
    GASTROENTEROLOGIA Y HEPATOLOGIA, 2010, 33 (05): : 382 - 390
  • [47] Risk factors and possibility of prevention in pancreatic cancer
    Voidazan, Septimiu
    Sabau, Monica
    REVISTA ROMANA DE MEDICINA DE LABORATOR, 2009, 16 (03): : 13 - 19
  • [48] Epidemiology and Risk Factors for Exocrine Pancreatic Cancer in a Northern African Population
    Sellam F.
    Harir N.
    Khaled M.B.
    Mrabent N.M.
    Salah R.
    Diaf M.
    Journal of Gastrointestinal Cancer, 2015, 46 (2) : 126 - 130
  • [49] Risk factors and therapeutic targets in pancreatic cancer
    Woermann, Sonja Maria
    Alguel, Hana
    FRONTIERS IN ONCOLOGY, 2013, 3
  • [50] Impact of diabetes and modifiable risk factors on pancreatic cancer survival in a population-based study after adjusting for clinical factors
    Hsieh, Mei-Chin
    Zhang, Lu
    Velasco-Gonzalez, Cruz
    Yi, Yong
    Pareti, Lisa A.
    Trapido, Edward J.
    Chen, Vivien W.
    Wu, Xiao-Cheng
    CANCER CAUSES & CONTROL, 2022, 33 (01) : 37 - 48