Pancreatic Cancer: A Review of Risk Factors

被引:3
作者
Grigorescu, Raluca Roxana [1 ]
Husar-Sburlan, Ioana Alexandra [2 ]
Gheorghe, Cristian [3 ]
机构
[1] Carol Davila Univ Med & Pharm, Sfanta Maria Hosp, Gastroenterol Dept, Bucharest 020021, Romania
[2] Sfanta Maria Hosp, Gastroenterol Dept, Bucharest 011172, Romania
[3] Carol Davila Univ Med & Pharm, Fundeni Clin Inst, Ctr Digest Dis & Liver Transplantat, Bucharest 020021, Romania
来源
LIFE-BASEL | 2024年 / 14卷 / 08期
关键词
pancreatic cancer; risk factors; obesity; microbiota; diabetes; PAPILLARY MUCINOUS NEOPLASMS; RENIN-ANGIOTENSIN SYSTEM; ABO BLOOD-GROUP; IMPAIRED GLUCOSE-TOLERANCE; BRCA2 GERMLINE MUTATIONS; PEUTZ-JEGHERS-SYNDROME; LONG-TERM SURVIVAL; HEPATITIS-B-VIRUS; FACTOR-I RECEPTOR; VITAMIN-D STATUS;
D O I
10.3390/life14080980
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Pancreatic adenocarcinoma is one of the most lethal types of gastrointestinal cancer despite the latest medical advances. Its incidence has continuously increased in recent years in developed countries. The location of the pancreas can result in the initial symptoms of neoplasia being overlooked, which can lead to a delayed diagnosis and a subsequent reduction in the spectrum of available therapeutic options. The role of modifiable risk factors in pancreatic cancer has been extensively studied in recent years, with smoking and alcohol consumption identified as key contributors. However, the few screening programs that have been developed focus exclusively on genetic factors, without considering the potential impact of modifiable factors on disease occurrence. Thus, fully understanding and detecting the risk factors for pancreatic cancer represents an important step in the prevention and early diagnosis of this type of neoplasia. This review reports the available evidence on different risk factors and identifies the areas that could benefit the most from additional studies.
引用
收藏
页数:34
相关论文
共 50 条
  • [21] Updated risk factors to inform early pancreatic cancer screening and identify high risk patients
    Principe, Daniel R.
    Rana, Ajay
    CANCER LETTERS, 2020, 485 : 56 - 65
  • [22] Research status of risk factors and prevention of pancreatic cancer: A bibliometric and visual analysis
    Song, Lichen
    Wang, Guihua
    Chen, Ziyi
    Wang, Guangming
    MEDICINE, 2025, 104 (11) : e41831
  • [23] Pancreatic cancer trends in Europe: epidemiology and risk factors
    Hawksworth, Graeme
    Hales, Jake
    Martinez, Fransico
    Hynes, Allen
    Hamilton, Angela
    Fernandez, Veronica
    MEDICAL STUDIES-STUDIA MEDYCZNE, 2019, 35 (02) : 164 - 171
  • [24] Risk factors and prognostic index model for pancreatic cancer
    Huang, Hui
    Sun, Jichun
    Jiang, Zheming
    Zhang, Xianlin
    Li, Zheng
    Zhu, Hongwei
    Yu, Xiao
    GLAND SURGERY, 2022, 11 (01) : 186 - 195
  • [25] Diabetes Mellitus and Obesity as Risk Factors for Pancreatic Cancer
    Eibl, Guido
    Cruz-Monserrate, Zobeida
    Korc, Murray
    Petrov, Maxim S.
    Goodarzi, Mark O.
    Fisher, William E.
    Habtezion, Aida
    Lugea, Aurelia
    Pandol, Stephen J.
    Hart, Phil A.
    Andersen, Dana K.
    JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS, 2018, 118 (04) : 555 - 567
  • [26] Risk factors of pancreatic cancer and their possible uses in diagnostics
    LANG, Jitka
    KUNOVSKY, Lumir
    KALA, Zdenek
    TRNA, Jan
    NEOPLASMA, 2021, 68 (02) : 227 - 239
  • [27] Reproductive and Hormonal Factors and Pancreatic Cancer Risk in Women
    Lucenteforte, Ersilia
    Zucchetto, Antonella
    Bosetti, Cristina
    Talamini, Renato
    Negri, Eva
    Serraino, Diego
    Franceschi, Silvia
    Lipworth, Loren
    La Vecchia, Carlo
    PANCREAS, 2011, 40 (03) : 460 - 463
  • [28] High risk factors of pancreatic carcinoma
    Camara, Soriba Naby
    Yin, Tao
    Yang, Ming
    Li, Xiang
    Gong, Qiong
    Zhou, Jing
    Zhao, Gang
    Yang, Zhi-yong
    Aroun, Tajoo
    Kuete, Martin
    Ramdany, Sonam
    Camara, Alpha Kabinet
    Diallo, Aissatou Taran
    Feng, Zhen
    Ning, Xin
    Xiong, Jiong-xin
    Tao, Jing
    Qin, Qi
    Zhou, Wei
    Cui, Jing
    Huang, Min
    Guo, Yao
    Gou, Shan-miao
    Wang, Bo
    Liu, Tao
    Olivier, Ohoya Etsaka Terence
    Conde, Tenin
    Cisse, Mohamed
    Magassouba, Aboubacar Sidiki
    Ballah, Sneha
    Keita, Naby Laye Moussa
    Souare, Ibrahima Sory
    Toure, Aboubacar
    Traore, Sadamoudou
    Balde, Abdoulaye Korse
    Keita, Namory
    Camara, Naby Daouda
    Emmanuel, Dusabe
    Wu, He-shui
    Wang, Chun-you
    JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES, 2016, 36 (03) : 295 - 304
  • [29] Review of screening for pancreatic cancer in high risk individuals
    Alina Stoita
    Ian D Penman
    David B Williams
    World Journal of Gastroenterology, 2011, 17 (19) : 2365 - 2371
  • [30] Environmental Risk Factors of Pancreatic Cancer
    Tsai, Hui-Jen
    Chang, Jeffrey S.
    JOURNAL OF CLINICAL MEDICINE, 2019, 8 (09)