Pediatric reference values of NT-proBNP and Galectin-3 based on a French cohort

被引：0

作者：

Gravrand, Victor ^{[1
]}

Lefebvre, Corentin S. ^{[1
]}

Hamza, Fatma ^{[1
]}

Della-Negra, Thibaud ^{[1
]}

Coyaud, Vincent ^{[1
]}

Vasseur, Axelle ^{[1
]}

Hennequin, Carole ^{[1
]}

Nivet-Antoine, Valerie ^{[1
,2
]}

Schaffner, Damien ^{[3
,4
]}

机构：

[1] Necker Enfants Malad Hosp, AP HP, Dept Biochem, F-75015 Paris, France

[2] Univ Paris Cite, INSERM, Innovat Therapies Haemostasis, Paris, France

[3] Necker Enfants Malad Hosp, AP HP, Dept Pediat Cardiac Surg, Paris, France

[4] Lausanne Univ Hosp, Women & Child Dept, Pediat Cardiol Unit, Lausanne, Switzerland

来源：

CLINICA CHIMICA ACTA | 2025年 / 564卷

关键词：

NT-proBNP; Galectin-3; Pediatric reference values; Cardiac biomarkers; BRAIN NATRIURETIC PEPTIDE; DIAGNOSIS; POPULATION; STABILITY; INFANTS;

D O I：

10.1016/j.cca.2024.119925

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background: In pediatric cardiology, the fact that some new biomarkers have assay-specific normal values has to be considered for correct clinical decisions. The current study aimed to provide age-adjusted normative values for NT-proBNP and Galectin-3 using the Abbott immunoassay system from a prospective French pediatric cohort sera collection and to validate our data for NT-proBNP on a second retrospective cohort. Methods: We analyzed 283 consecutive samples for NT-proBNP and 140 samples for Galectin-3 collected from apparently healthy children (0-18 years) with outpatient treatment at our institution (Hopital Necker-Enfants malades, Paris, France) during 24 months. Results: For NT-proBNP and Galectin-3, we establish four age partitions, respectively two (<2 years / >2 years) and establish upper reference values and their 90 % CI for each biomarker (Galectin-3 (ng/mL): 56 [44-70] / 26 [23-29]). We evaluated the diagnostic performance of our upper reference values of NT-proBNP on a retrospective cohort (n = 428) with positive predictive value of 0.92. Conclusions: Using Abbott immunoassay system, we report age-specific reference values for NT-proBNP and for the first time for Galectin-3 in a healthy French pediatric cohort. These data call for larger cohort studies to define more robustly percentiles and diagnostic performance for NT-proBNP.

引用

页数：7