Polyamidoamine Dendrimers: Brain-Targeted Drug Delivery Systems in Glioma Therapy

被引：2

作者：

Yan, Xinyi ^{[1
]}

Chen, Qi ^{[2
]}

机构：

[1] Zhejiang Chinese Med Univ, Sch Pharmaceut Sci, Key Lab Neuropharmacol & Translat Med Zhejiang Pro, Hangzhou 310053, Peoples R China

[2] Fuzhou Univ, Interdisciplinary Inst Med Engn, Fuzhou 350108, Peoples R China

来源：

POLYMERS | 2024年 / 16卷 / 14期

基金：

中国国家自然科学基金;

关键词：

PAMAM dendrimers; brain-targeted; drug delivery system; glioma; CO-MODIFIED PAMAM; IN-VITRO; ANTICANCER DRUG; POLY(AMIDOAMINE) DENDRIMERS; NANOPARTICLES; NANOCARRIER; POLYMERS; BARRIER; CELLS; NANOMEDICINE;

D O I：

10.3390/polym16142022

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Glioma is the most common primary intracranial tumor, which is formed by the malignant transformation of glial cells in the brain and spinal cord. It has the characteristics of high incidence, high recurrence rate, high mortality and low cure rate. The treatments for glioma include surgical removal, chemotherapy and radiotherapy. Due to the obstruction of the biological barrier of brain tissue, it is difficult to achieve the desired therapeutic effects. To address the limitations imposed by the brain's natural barriers and enhance the treatment efficacy, researchers have effectively used brain-targeted drug delivery systems (DDSs) in glioma therapy. Polyamidoamine (PAMAM) dendrimers, as branched macromolecular architectures, represent promising candidates for studies in glioma therapy. This review focuses on PAMAM-based DDSs in the treatment of glioma, highlighting their physicochemical characteristics, structural properties as well as an overview of the toxicity and safety profiles.

引用

页数：16

共 117 条

[1] Dendrimers: synthesis, applications, and properties [J].

Abbasi, Elham ;

Aval, Sedigheh Fekri ;

Akbarzadeh, Abolfazl ;

Milani, Morteza ;

Nasrabadi, Hamid Tayefi ;

Joo, Sang Woo ;

Hanifehpour, Younes ;

Nejati-Koshki, Kazem ;

Pashaei-Asl, Roghiyeh .

NANOSCALE RESEARCH LETTERS, 2014, 9 :1-10

[2] Structure and function of the blood-brain barrier [J].

Abbott, N. Joan ;

Patabendige, Adjanie A. K. ;

Dolman, Diana E. M. ;

Yusof, Siti R. ;

Begley, David J. .

NEUROBIOLOGY OF DISEASE, 2010, 37 (01) :13-25

[3] Dendrimer Internalization and Intracellular Trafficking in Living Cells [J].

Albertazzi, Lorenzo ;

Serresi, Michela ;

Albanese, Alberto ;

Beltram, Fabio .

MOLECULAR PHARMACEUTICS, 2010, 7 (03) :680-688

[4]

Azar Negar Taghavi Pourian, 2013, HACETTEPE JOURNAL OF BIOLOGY AND CHEMISTRY, V41, P289

[5] Dipeptide-functionalized polyamidoamine dendrimer-mediated apoptin gene delivery facilitates apoptosis of human primary glioma cells [J].

Bae, Yoonhee ;

Green, Eric S. ;

Kim, Goo-Young ;

Song, Su Jeong ;

Mun, Ji Young ;

Lee, Sunray ;

Park, Jong-Il ;

Park, Jong-sang ;

Ko, Kyung Soo ;

Han, Jin ;

Choi, Joon Sig .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2016, 515 (1-2) :186-200

[6] Poly(amidoamine) (PAMAM): An emerging material for electrochemical bio(sensing) applications [J].

Bahadir, Elif Burcu ;

Sezginturk, Mustafa Kemal .

TALANTA, 2016, 148 :427-438

[7] Advancements and challenges in brain cancer therapeutics [J].

Bai, Fan ;

Deng, Yueyang ;

Li, Long ;

Lv, Ming ;

Razzokov, Jamoliddin ;

Xu, Qingnan ;

Xu, Zhen ;

Chen, Zhaowei ;

Chen, Guojun ;

Chen, Zhitong .

EXPLORATION, 2024, 4 (06)

[8] Glioma stem cells promote radioresistance by preferential activation of the DNA damage response [J].

Bao, Shideng ;

Wu, Qiulian ;

McLendon, Roger E. ;

Hao, Yueling ;

Shi, Qing ;

Hjelmeland, Anita B. ;

Dewhirst, Mark W. ;

Bigner, Darell D. ;

Rich, Jeremy N. .

NATURE, 2006, 444 (7120) :756-760

[9] Formation and maintenance of the BBB [J].

Blanchette, Marie ;

Daneman, Richard .

MECHANISMS OF DEVELOPMENT, 2015, 138 :8-16

[10] ENANTIOSELECTIVE CATALYSIS .85. OPTICALLY-ACTIVE EXPANDED CHELATE PHOSPHINES DERIVED FROM 1,OMEGA-BIS(DICHLOROPHOSPHINO)ALKANES [J].

BRUNNER, H ;

FURST, J .

TETRAHEDRON, 1994, 50 (15) :4303-4310

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