The Role of Muscarinic Acetylcholine Receptor M3 in Cardiovascular Diseases

被引：0
|
作者：
Liu, Xinxing [1 ]
Yu, Yi [1 ]
Zhang, Haiying [1 ]
Zhang, Min [1 ]
Liu, Yan [1 ,2 ,3 ,4 ]
机构：
[1] Hainan Med Univ, Hainan Acad Med Sci, Sch Pharm, Haikou 571199, Peoples R China
[2] Hainan Med Univ, Hainan Acad Med Sci, Engn Res Ctr Trop Med Innovat & Transformat, Minist Educ, Haikou 571199, Peoples R China
[3] Hainan Med Univ, Hainan Acad Med Sci, Int Joint Res Ctr Human Machine Intelligent Collab, Haikou 571199, Peoples R China
[4] Hainan Med Univ, Hainan Acad Med Sci, Hainan Prov Key Lab Res & Dev Trop Herbs, Haikou 571199, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 14期
基金：
中国国家自然科学基金;
关键词：
muscarinic acetylcholine receptor M-3; cardiomyocyte; endothelial cell; fibroblast; cardiovascular diseases; SMOOTH-MUSCLE; MEDIATING VASODILATION; CARDIAC-HYPERTROPHY; ELECTRICAL-ACTIVITY; ENDOTHELIAL-CELLS; MULTIPLE SUBTYPES; M3; RECEPTORS; ACTIVATION; HEART; HYPOXIA/REOXYGENATION;
D O I：
10.3390/ijms25147560
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The muscarinic acetylcholine receptor M-3 (M-3-mAChR) is involved in various physiological and pathological processes. Owing to specific cardioprotective effects, M-3-mAChR is an ideal diagnostic and therapeutic biomarker for cardiovascular diseases (CVDs). Growing evidence has linked M-3-mAChR to the development of multiple CVDs, in which it plays a role in cardiac protection such as anti-arrhythmia, anti-hypertrophy, and anti-fibrosis. This review summarizes M-3-mAChR's expression patterns, functions, and underlying mechanisms of action in CVDs, especially in ischemia/reperfusion injury, cardiac hypertrophy, and heart failure, opening up a new research direction for the treatment of CVDs.
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页数：14
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