Ferroptosis is Involved in the Pharmacological Effect of Ginsenoside

被引：2

作者：

Feng, Juling ^{[1
,2
]}

Chen, Haodong ^{[1
,2
]}

Liu, Yangbo ^{[1
,2
]}

Ai, Qidi ^{[1
,2
]}

Yang, Yantao ^{[1
,2
]}

He, Wenbin ^{[5
]}

Zhao, Lei ^{[4
]}

Chu, Shifeng ^{[3
]}

Chen, Naihong ^{[1
,2
,3
]}

机构：

[1] Hunan Univ Chinese Med, Changsha 410208, Hunan, Peoples R China

[2] Hunan Engn Technol Ctr Standardizat & Funct Chine, Changsha 410208, Hunan, Peoples R China

[3] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Medica & Neurosci Ctr, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

[4] Univ South China, Hengyang Med Coll, Res Lab Translat Med, Hengyang 421001, Hunan, Peoples R China

[5] Shanxi Univ Tradit Chinese Med, Shanxi Key Lab Tradit Chinese Med Encephalopathy, Taiyuan 030024, Peoples R China

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2024年 / 24卷 / 13期

基金：

中国国家自然科学基金; 北京市自然科学基金;

关键词：

Ginsenoside; ferroptosis; pharmacological target; iron metabolism; lipid metabolism; amino acid metabolism; GLUTATHIONE-PEROXIDASE; 4; CELL-DEATH; OXIDATIVE STRESS; CANCER-CELLS; PARKINSONS-DISEASE; IRON; PROTECTS; INACTIVATION; CONTRIBUTES; SUPPRESSES;

D O I：

10.2174/0113895575277359231210145922

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ginsenoside is the principal active ingredient in ginseng. Several investigations have found that ginsenosides have anti-inflammatory, antioxidant, anti-apoptotic, anti-cancer, and anti-allergic activities. Ferroptosis is an iron-dependent, non-apoptotic form of cell-regulated death caused by lipid peroxidation. Iron, lipid, and amino acid metabolism orchestrate the complex ferroptosis response through direct or indirect regulation of iron accumulation or lipid peroxidation. More and more research has demonstrated that ginsenoside impacts illnesses via ferroptosis, implying that ferroptosis might be employed as a novel target of ginsenoside for disease therapy. This article examines the molecular mechanism of ferroptosis as well as the current advancement of ginsenoside in influencing disorders via ferroptosis.

引用

页码：1228 / 1237

页数：10