Visible Light-Induced Radical Tandem Cyclization of o-Isocyanodiaryl Amines with Arylthiodifluoroalkyl 2-Pyridyl Sulfones or Difluormethyl- Bromides

被引：1
作者：
Liang, Yong-Xin [1 ,2 ]
Ai, Qing-Wen [2 ]
Yang, Zi-Xuan [2 ]
Zhao, Yu-Long [2 ]
机构：
[1] Qilu Normal Univ, Coll Chem & Chem Engn, Jinan 250200, Peoples R China
[2] Northeast Normal Univ, Fac Chem, Jilin Prov Key Lab Organ Funct Mol Design & Synth, Changchun 130024, Peoples R China
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 27卷 / 41期
关键词：
Photocatalytic; o-Isocyanodiaryl amines; Arylthiodifluoroalkyl 2-pyridyl sulfones; Difluormethyl bromides; Dibenzodiazepines; NITROGEN-HETEROCYCLES; FUNCTIONALIZATION; ISOCYANIDES; ISONITRILES; DERIVATIVES; FLUORINE; KETONES;
D O I：
10.1002/ejoc.202400731
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A visible-light-induced photoredox-catalyzed radical tandem cyclization of o-isocyanodiaryl amines with arylthiodifluoroalkyl 2-pyridyl sulfones or difluormethyl bromides has been realized for the first time. The reaction works with a broad range of substrates and provides a simple and efficient method for the synthesis of 11-difluoromethyl-substituted dibenzodiazepines from easily available starting materials in very mild conditions.
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页数：6
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