Impact of immunotherapy on liver metastasis

被引：0
作者：
Fu, Zhuo [1 ]
Wang, Ming-Wei [2 ]
Liu, Ya-Hui [3 ]
Jiao, Yan [3 ]
机构：
[1] Inner Mongolia Minzu Univ, Med Coll, Tongliao 028000, Inner Mongolia, Peoples R China
[2] Jilin Univ, Sch Publ Hlth, Minist Hlth, Key Lab Radiobiol, Changchun 130000, Jilin, Peoples R China
[3] Jilin Univ, Gen Surg Ctr, Dept Hepatobiliary & Pancreat Surg, Hosp 1, 71 Xinmin St, Changchun 130021, Jilin, Peoples R China
来源：
WORLD JOURNAL OF GASTROINTESTINAL SURGERY | 2024年 / 16卷 / 07期
关键词：
Immunotherapy; Liver metastasis; Tumor microenvironment; Resistance; T cells; CANCER; MICROENVIRONMENT; RESISTANCE; EFFICACY;
D O I：
10.4240/wjgs.v16.i7.1969
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
This editorial discusses the article "Analysis of the impact of immunotherapy efficacy and safety in patients with gastric cancer and liver metastasis" published in the latest edition of the World Journal of Gastrointestinal Surgery. Immunotherapy has achieved outstanding success in tumor treatment. However, the presence of liver metastasis (LM) restrains the efficacy of immunotherapy in various tumors, including lung cancer, colorectal cancer, renal cell carcinoma, melanoma, and gastric cancer. A decrease in CD8+ T cells and nature killer cells, along with an increase in macrophages and regulatory T cells, was observed in the microenvironment of LM, leading to immunotherapy resistance. More studies are necessary to determine the best strategy for enhancing the effectiveness of immunotherapy in patients with LM.
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页数：5
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