Major vault protein directly enhances adaptive immunity induced by Influenza A virus or indirectly through innate immunity

被引：0

作者：

Ma, Caijiao ^{[1
]}

Luo, Chuanjin ^{[1
]}

Deng, Feiyan ^{[1
]}

Yu, Chen ^{[1
]}

Chen, Yumeng ^{[1
]}

Zhong, Gechang ^{[1
]}

Zhan, Yuxin ^{[1
]}

Nie, Longyu ^{[1
]}

Huang, Yu ^{[1
]}

Xia, Yongfang ^{[1
]}

Cai, Zeng ^{[1
]}

Xu, Ke ^{[1
]}

Cai, Huanhuan ^{[2
]}

Wang, Fubing ^{[3
]}

Lu, Zhibing ^{[2
]}

Zeng, Xiangtai ^{[4
]}

Zhu, Ying ^{[1
]}

Liu, Shi ^{[1
,2
,3
,4
]}

机构：

[1] Wuhan Univ, Coll Life Sci, Frontier Sci Ctr Immunol & Metab, State Key Lab Virol,Modern Virol Res Ctr,Taikang C, Wuhan 430072, Peoples R China

[2] Wuhan Univ, Zhongnan Hosp, Inst Myocardial Injury & Repair, Dept Cardiol, Wuhan 430072, Peoples R China

[3] Chinese Acad Med Sci, Wuhan Res Ctr Infect Dis & Canc, Wuhan 430072, Peoples R China

[4] Gannan Med Univ, Affiliated Hosp 1, Dept Gen Surg, Ganzhou Key Lab Thyroid Canc, Ganzhou 341000, Jiangxi, Peoples R China

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2024年 / 1870卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Major vault protein; Influenza a virus; Antibody; B cells; T cells; Dendritic cells; CLASS-I; CELL RESPONSE; T-CELLS; RESISTANCE; INDUCTION; CLEARANCE; PARTICLES; PLAYS; PTEN;

D O I：

10.1016/j.bbadis.2024.167441

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As we previously revealed, major vault protein (MVP) is a virus-induced host factor, and its expression is crucial for innate immune responses. Nevertheless, the function of MVP in adaptive immunity is poorly known. Here, we demonstrate that Mvp knockout mice had attenuated antibody responses and reduced survival after rechallenge with homologous influenza A virus (IAV) relative to wild-type mice. Analysis of B cell populations showed that MVP promoted germinal center (GC) responses to develop optimal antiviral humoral immunity. Although MVPdeficient T cells and dendritic cells (DCs) were not intrinsically damaged, MVP promoted activating effector T cells and T follicular helper responses and regulated specific DC subsets. These findings suggest that MVP directs an effective adaptive immune response against IAV by directly engaging in GC reactions or indirectly augmenting cellular immunity via innate immune pathways.

引用

页数：9

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