Hydrophilic silsesquioxane nanocages toughened extracellular matrix biomimetic Poly(γ-Glutamic acid) multidimensional self-polymerizable and osteogenic hybrid hydrogel for osteoporotic bone regeneration

被引：3

作者：

Liu, Lingli ^{[1
,2
,3
]}

Ma, Shiyuan ^{[2
]}

Xiao, Zhisheng ^{[1
]}

Li, Jintao ^{[1
]}

Wang, Yue ^{[2
]}

Lu, Zhihui ^{[2
,3
]}

Zhao, Yitao ^{[1
]}

Guo, Jinshan ^{[1
,2
,3
,4
]}

机构：

[1] Southern Med Univ, Affiliated Hosp 3, Orthoped Hosp Guangdong Prov, Ctr Orthoped Surg,Sch Clin Med 3,Guangdong Prov Ke, Guangzhou 510630, Guangdong, Peoples R China

[2] Southern Med Univ, Sch Basic Med Sci, Dept Histol & Embryol, NMPA Key Lab Safety Evaluat Cosmet, Guangzhou 510515, Peoples R China

[3] Huangpu Inst Mat, Regenerat Med & Tissue Repair Mat Res Ctr, 88 Yonglong Ave Xinlong Town, Guangzhou 511363, Peoples R China

[4] Chinese Acad Sci, Changchun Inst Appl Chem, CAS Key Lab High Performance Synthet Rubber & Comp, 5625 Renmin St, Changchun 130022, Peoples R China

来源：

COMPOSITES PART B-ENGINEERING | 2024年 / 284卷

关键词：

Osteoporotic bone regeneration; Hydrophilic NH 2-T4-POSS; Organic/inorganic hybrid; Multidimensional self-polymerizable hydrogel; Balance immune micro-environment; SCAFFOLDS;

D O I：

10.1016/j.compositesb.2024.111713

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Rapid bone defect regeneration in osteoporotic conditions remains a significant challenge due to the fragile mechanical stability and pathological microenvironment. The absence of bone matrix is the primary characteristic of these defects, and advanced strategies for treating osteoporotic bone defects focus on remodeling the bone matrix ' s spatial structure and regulating the microenvironment. While many hydrogels have been developed for bone regeneration, their use in repairing osteoporotic bone defects is constrained by deficiencies in shape-adaptivity, weak osteogenic bioactivity, and lack of physiological mechanical support. Herein, a novel bioactive hydrophilic semi-caged NH 2-T4 silsesquioxane (NH 2-T4-POSS) nanocage was developed, which was used to modify gamma-polyglutamic acid ( gamma-PGA) together with dopamine, to give an organic/inorganic hybrid hydrogel PGA-DA &T4 for osteoporotic bone regeneration. The developed PGA-DA &T4 hydrogel possesses favorable injectability, shape-adaptivity, self-healability, and strong antioxidant ability. Benefited from organic/ inorganic hybridation and multidimensional molecular interacting mechanism, PGA-DA &T4 exhibites enhanced thermal stability and longer degradation period, unique self-polymerizability, high elasticity, and considerable tissue adhesion ability. In vitro experiments proved that PGA-DA &T4 is biocompatible, and is able to promote cell migration and neovascularization, and possesses favorable immunoregulatory to promote macrophage polarization towards anti-inflammatory M2 phenotype. Furthermore, PGA-DA &T4 has been demonstrated to accelerate osteogenic differentiation and inhibit osteoclastogenesis, thereby promoting the repair of osteoporotic bone defects. Our research successfully developed a novel hybrid gamma-PGA hydrogel with therapeutic effects and supplied a promising biomaterial with potential clinical application for repairing osteoporotic bone defects.

引用

页数：18