The Impact of the Mediterranean Diet on Telomere Biology: Implications for Disease Management-A Narrative Review

被引：11

作者：

Baliou, Stella ^{[1
,2
]}

Ioannou, Petros ^{[3
]}

Apetroaei, Miruna-Maria ^{[4
]}

Vakonaki, Elena ^{[1
,2
]}

Fragkiadaki, Persefoni ^{[1
,2
]}

Kirithras, Evangelos ^{[1
,2
]}

Tzatzarakis, Manolis N. ^{[1
]}

Arsene, Andreea Letitia ^{[4
]}

Docea, Anca Oana ^{[5
,6
]}

Tsatsakis, Aristides ^{[1
,2
]}

机构：

[1] Univ Crete, Med Sch, Lab Toxicol, Iraklion 71003, Greece

[2] Lifeplus SA, Sci & Technol Pk Crete, C Bldg, Vassilika Vouton 70013, Heraklion, Greece

[3] Univ Crete, Sch Med, Iraklion 71003, Greece

[4] Carol Davila Univ Med & Pharm, Fac Pharm, 6 Traian Vuia St, Bucharest 020956, Romania

[5] Univ Med & Pharm Craiova, Dept Toxicol, Craiova 200349, Romania

[6] Univ Med & Pharm, Fac Pharm, Dept Toxicol, Craiova 200349, Romania

来源：

NUTRIENTS | 2024年 / 16卷 / 15期

关键词：

telomere length; Mediterranean diet; polyphenols; vitamins; minerals; fatty acids; antioxidant; anti-inflammatory; diseases; autoimmunity; POLYUNSATURATED FATTY-ACIDS; CARDIOVASCULAR-DISEASE; OXIDATIVE-STRESS; VITAMIN-D; DNA-DAMAGE; GREEN TEA; ANTIOXIDANT CAPACITY; GENOMIC INSTABILITY; HOMOCYSTEINE LEVELS; METABOLIC SYNDROME;

D O I：

10.3390/nu16152525

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Introduction: Telomeres are nucleoprotein complexes at the ends of chromosomes that are under the control of genetic and environmental triggers. Accelerated telomere shortening is causally implicated in the increasing incidence of diseases. The Mediterranean diet has recently been identified as one that confers protection against diseases. This review aimed to identify the effect of each component of the Mediterranean diet on telomere length dynamics, highlighting the underlying molecular mechanisms. Methods: PubMed was searched to identify relevant studies to extract data for conducting a narrative review. Results: The Mediterranean diet alleviates clinical manifestations in many diseases. Focusing on autoimmune diseases, the Mediterranean diet can be protective by preventing inflammation, mitochondrial malfunction, and abnormal telomerase activity. Also, each Mediterranean diet constituent seems to attenuate aging through the sustenance or elongation of telomere length, providing insights into the underlying molecular mechanisms. Polyphenols, vitamins, minerals, and fatty acids seem to be essential in telomere homeostasis, since they inhibit inflammatory responses, DNA damage, oxidative stress, mitochondrial malfunction, and cell death and induce telomerase activation. Conclusions: The Mediterranean diet is beneficial for maintaining telomere dynamics and alleviating age-related illnesses. This review provides a comprehensive overview of cross-sectional, observational, and randomized controlled trials regarding the beneficial impact of every constituent in the Mediterranean diet on telomere length and chronic disease management.

引用

页数：28

共 207 条

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