Pathophysiology, Clinical Manifestations and Diagnosis of Immune Thrombocytopenia: Contextualization from a Historical Perspective

被引:9
作者
Martinez-Carballeira, Daniel [1 ,2 ]
Bernardo, Angel [1 ,2 ]
Caro, Alberto [1 ,2 ]
Soto, Inmaculada [1 ,2 ]
Gutierrez, Laura [2 ,3 ]
机构
[1] Hosp Univ Cent Asturias HUCA, Dept Hematol, Oviedo 33011, Spain
[2] Inst Invest Sanitaria Principado Asturias ISPA, Platelet Res Lab, Oviedo 33011, Spain
[3] Univ Oviedo, Dept Med, Oviedo, Spain
关键词
antiplatelet antibodies; clinical manifestations; diagnosis; history; immune thrombocytopenia (ITP); pathogenesis; platelets; HELICOBACTER-PYLORI INFECTION; ADULT PATIENTS; VENOUS THROMBOEMBOLISM; MEGAKARYOCYTE GROWTH; PLATELET PRODUCTION; FOLLOW-UP; T-CELLS; PURPURA; ITP; THROMBOPOIETIN;
D O I
10.3390/hematolrep16020021
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by an isolated decrease in the platelet count and an increased risk of bleeding. The pathogenesis is complex, affecting multiple components of the immune system and causing both peripheral destruction of platelets and impaired central megakaryopoiesis and platelet production in the bone marrow. Here, we intend to contextualize the current knowledge on the pathophysiology, terminology, epidemiology, clinical manifestations, diagnosis, and prognosis of ITP from a historical perspective and the first references to the never-stopping garnering of knowledge about this entity. We highlight the necessity to better understand ITP in order to be able to provide ITP patients with personalized treatment options, improving disease prognosis and reducing the incidence or frequency of refractoriness.
引用
收藏
页码:204 / 219
页数:16
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