Wireless Optogenetic Targeting Nociceptors Helps Host Cells Win the Competitive Colonization in Implant-Associated Infections

被引：0

作者：

Fang, Xinyu ^{[1
,2
,3
]}

Ding, Haiqi ^{[1
,2
,3
]}

Chen, Yang ^{[1
,2
,3
]}

Wang, Qijin ^{[1
,2
,3
,4
]}

Yuan, Xuhui ^{[1
,2
,3
]}

Zhang, Chaofan ^{[1
,2
,3
]}

Huang, Jiagu ^{[5
]}

Huang, Jiexin ^{[6
]}

Lv, Jianhua ^{[7
]}

Hu, Hongxin ^{[7
]}

Huang, Changyu ^{[8
]}

Hu, Xueni ^{[9
,10
]}

Lin, Yiming ^{[1
,2
,3
]}

Zhang, Nanxin ^{[1
,2
,3
]}

Zhou, Wei ^{[1
,2
,3
]}

Huang, Ying ^{[1
,2
,3
]}

Li, Wenbo ^{[1
,2
,3
]}

Niu, Susheng ^{[11
]}

Wu, Zhaoyang ^{[1
,2
,3
]}

Lin, Jianhua ^{[1
,2
,3
]}

Yang, Bin ^{[9
,10
]}

Yuan, Tifei ^{[12
]}

Zhang, Wenming ^{[1
,2
,3
]}

机构：

[1] Fujian Med Univ, Binhai Campus Affiliated Hosp 1, Natl Reg Med Ctr, Dept Orthoped Surg, Fuzhou 350000, Peoples R China

[2] Fujian Med Univ, Dept Orthoped Surg, Affiliated Hosp 1, Fuzhou 350000, Peoples R China

[3] Fujian Med Univ, Affiliated Hosp 1, Fujian Prov Inst Orthoped, Fuzhou 350000, Peoples R China

[4] Fujian Med Univ, Dept Orthoped, Affiliated Mindong Hosp, Fuan 355000, Peoples R China

[5] Ningde municipal Hosp, Dept Orthoped Surg, Ningde 352000, Peoples R China

[6] Nanping First Hosp, Dept Orthoped Surg, Nanping 353000, Peoples R China

[7] Putian Univ, Dept Orthoped Surg, Affiliated Hosp, Putian 351100, Peoples R China

[8] Quanzhou Orthoped Traumatol Hosp, Dept Orthopaed Surg, Quanzhou, Peoples R China

[9] Fujian Med Univ, Dept Lab Med, Affiliated Hosp 1, Fuzhou 350000, Peoples R China

[10] Fujian Med Univ, Binhai Campus Affiliated Hosp 1, Natl Reg Med Ctr, Dept Lab Med, Fuzhou 350000, Peoples R China

[11] Fujian Univ Tradit Chinese Med, Key Lab Orthoped & Traumatol Tradit Chinese Med &, Minist Educ, Fuzhou 350000, Peoples R China

[12] Shanghai Jiao Tong Univ, Brain Hlth Inst, Natl Ctr Mental Disorders, Shanghai Mental Hlth Ctr,Sch Med, Shanghai 200000, Peoples R China

来源：

SMALL METHODS | 2024年

基金：

中国国家自然科学基金;

关键词：

anticipatory immunity; implant surface competition; implant-associated infections; nociceptors; optogenetics; SMALL-COLONY VARIANTS; STAPHYLOCOCCUS-AUREUS; SENSORY NEURONS; OPTOELECTRONICS; IDENTIFICATION; PHARMACOLOGY; PERFORMANCE; IMMUNITY; FATIGUE; TIME;

D O I：

10.1002/smtd.202400216

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The role of nociceptive nerves in modulating immune responses to harmful stimuli via pain or itch induction remains controversial. Compared to conventional surgery, various implant surgeries are more prone to infections even with low bacterial loads. In this study, an optogenetic technique is introduced for selectively activating peripheral nociceptive nerves using a fully implantable, wirelessly rechargeable optogenetic device. By targeting nociceptors in the limbs of awake, freely moving mice, it is found that activation induces anticipatory immunity in the innervated territory and enhances the adhesion of various host cells to the implant surface. This effect mediates acute immune cell-mediated killing of Staphylococcus aureus on implants and enables the host to win "implant surface competition" against Staphylococcus aureus. This finding provides new strategies for preventing and treating implant-associated infections.

引用

页数：19

共 5 条

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