Treatment of Locally Recurrent Rectal Cancer

被引：0

作者：

Regan, Samuel N. ^{[1
]}

Hendren, Samantha ^{[2
]}

Krauss, John C. ^{[3
]}

Crysler, Oxana V. ^{[3
]}

Cuneo, Kyle C. ^{[1
]}

机构：

[1] Univ Michigan, Dept Radiat Oncol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Surg, Div Colorectal Surg, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Internal Med, Div Hematol Oncol, Ann Arbor, MI 48109 USA

来源：

CANCER JOURNAL | 2024年 / 30卷 / 04期

关键词：

Local recurrence; radiation therapy; rectal cancer; salvage; surgery; TOTAL MESORECTAL EXCISION; DOSE-RATE BRACHYTHERAPY; LONG-TERM OUTCOMES; COLORECTAL-CANCER; SURGERY; REIRRADIATION; RESECTION; THERAPY; CHEMOTHERAPY; RADIOTHERAPY;

D O I：

10.1097/PPO.0000000000000728

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Up to 10% of patients with locally advanced rectal cancer will experience locoregional recurrence. In the setting of prior surgery and often radiation and chemotherapy, these represent uniquely challenging cases. When feasible, surgical resection offers the best chance for oncologic control yet risks significant morbidity. Studies have consistently indicated that a negative surgical resection margin is the strongest predictor of oncologic outcomes. Chemoradiation is often recommended to increase the chance of an R0 resection, and in cases of close/positive margins, intraoperative radiation/brachytherapy can be utilized. In patients who are not surgical candidates, radiation can provide symptomatic relief. Ongoing phase III trials are aiming to address questions regarding the role of reirradiation and induction multiagent chemotherapy regimens in this population.

引用

页码：264 / 271

页数：8

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