Blood-Brain Barrier Disruption and Imaging Assessment in Stroke

被引：6

作者：

Liang, Yuchen ^{[1
]}

Jiang, Yueluan ^{[2
]}

Liu, Jiaxin ^{[1
]}

Li, Xuewei ^{[1
]}

Cheng, Xinyue ^{[1
]}

Bao, Lei ^{[1
]}

Zhou, Hongwei ^{[1
]}

Guo, Zhenni ^{[3
,4
]}

机构：

[1] Jilin Univ, Hosp 1, Dept Radiol, Changchun, Peoples R China

[2] Diagnost Imaging Siemens Healthineers Ltd, MR Res & Collaborat Team, Beijing, Peoples R China

[3] Jilin Univ, Hosp 1, Stroke Ctr, Dept Neurol, Changchun, Peoples R China

[4] Jilin Univ, Neurosci Res Ctr, Hosp 1, Dept Neurol, Changchun, Peoples R China

来源：

TRANSLATIONAL STROKE RESEARCH | 2024年

关键词：

Blood-brain barrier; Ischemic stroke; Hemorrhagic transformation; PCT; DCE-MRI; ACUTE ISCHEMIC-STROKE; PREDICTS HEMORRHAGIC TRANSFORMATION; PERMEABILITY DERANGEMENTS; MATRIX METALLOPROTEINASES; REVERSIBLE DISRUPTION; HEALTH; PATHOGENESIS; CIRCULATION; EXPRESSION; PATTERNS;

D O I：

10.1007/s12975-024-01300-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Disruption of the blood-brain barrier (BBB) is an important pathological hallmark of ischemic stroke. Blood-brain barrier disruption (BBBD) is a consequence of ischemia and may also exacerbate damage to brain parenchyma. Therefore, maintaining BBB integrity is critical for the central nervous system (CNS) homeostasis. This review offers a concise overview of BBB structure and function, along with the mechanisms underlying its impairment following a stroke. In addition, we review the recent imaging techniques employed to study blood-brain barrier permeability (BBBP) in the context of ischemic brain injury with the goal of providing imaging guidance for stroke diagnosis and treatment from the perspective of the BBBD. This knowledge is vital for developing strategies to safeguard the BBB during cerebral ischemia.

引用

页码：1400 / 1411

页数：12

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