A Gd(iii)-labelled self-assembling peptide as a potential pH-responsive MRI contrast agent

被引：1
|
作者：
Ocampo, Carlo Martin M. [1 ]
Villaraza, Aaron Joseph L. [1 ]
机构：
[1] Univ Philippines Diliman, Inst Chem, Quezon City, Philippines
来源：
DALTON TRANSACTIONS | 2024年 / 53卷 / 36期
关键词：
RESONANCE; RELAXIVITY; SIZE;
D O I：
10.1039/d4dt01773k
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A marine-derived peptide labelled with a Gd(III)-chelate was found to self-assemble depending on the solution pH, accompanied by changes in T-1-relaxivity (r(1)) values when in the dispersed or self-assembled form. Such pH-responsive behavior can be advantageous in the development of macromolecular magnetic resonance imaging (MRI) contrast agents which monitor the tissue physiology.
引用
收藏
页码：14971 / 14974
页数：4
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