Simultaneous Occurrence of Nanospheres and Nanofibers Self-Assembled from Achiral Tripeptides

被引：2

作者：

Vardhishna, Malapaka Venkata ^{[1
]}

Srinivasulu, Gannoju ^{[1
]}

Harikrishna, Adicherl ^{[2
]}

Thakur, Suman Siddharth ^{[2
]}

Chatterjee, Bhaswati ^{[1
]}

机构：

[1] NIPER Hyderabad, NIPER, Dept Pharmaceut, Govt India,Minist Chem & Fertilizers, Hyderabad 500037, Telangana, India

[2] Ctr Cellular & Mol Biol, Lab E409, Prote & Cell Signaling, Uppal Rd, Hyderabad 500007, India

来源：

CHEMISTRYOPEN | 2019年 / 8卷 / 03期

关键词：

electron microscopy; nanofibers; nanospheres; peptides; self-assembly; STRUCTURAL TRANSITION; DIPHENYLALANINE PEPTIDE; DIPEPTIDE NANOTUBES; SOLVENT; FABRICATION;

D O I：

10.1002/open.201800258

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The achiral tripeptide Boc-Aib-MABA-Aib-OMe has the ability to co-exist as nanospheres and as a network of nanofibers in methanol. Furthermore, AFM and TEM images show the presence of bulges in the network of nanofibers. Interestingly, the formation of nanofibers is seen to emerge from the outer boundary of the spherical structures. Some of the nanofibers curl up at the tip and later result in the formation of hollow nanospheres with thick boundaries. The presence of beta-turn-like structures with hydrogen bonding is observed using FT-IR studies. The presence of hydrogen bonding is also demonstrated by using NMR studies.

引用

页码：266 / 270

页数：5

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