Encapsulation of biological molecules in metal-organic frameworks for biomedical applications: Recent developments and future perspectives

被引：3

作者：

Andarzbakhsh, Kamyab ^{[1
]}

Sharafi-Badr, Paria ^{[2
]}

Ehsandoost, Elham ^{[3
]}

Morad, Hamed ^{[4
]}

Rezazadeh, Amir ^{[5
]}

Kazemian, Hossein ^{[6
,7
,8
]}

机构：

[1] Islamic Azad Univ, Fac Pharm & Pharmaceut Sci, Dept Pharmaceut, Tehran Med Sci, Tehran, Iran

[2] Iran Univ Med Sci, Sch Pharm, Dept Pharmacognosy & Pharmaceut Biotechnol, Tehran, Iran

[3] Shiraz Univ, Dept Food Sci & Technol, Shiraz, Iran

[4] Iran Univ Med Sci, Sch Pharm, Dept Pharmaceut & Pharmaceut Nanotechnol, Tehran, Iran

[5] Iran Univ Med Sci, Sch Pharm, Dept Clin Pharm, Tehran, Iran

[6] Univ Northern British Columbia UNBC, Mat Technol & Environm Res Lab MATTER, Prince George, BC, Canada

[7] UNBC, Northern Analyt Lab Serv Northern BCs Environm & C, Prince George, BC, Canada

[8] UNBC, Fac Environm, Environm Sci Program, Prince George, BC, Canada

来源：

INORGANIC CHEMISTRY COMMUNICATIONS | 2024年 / 169卷

关键词：

Biological Metal-Organic Frameworks (Bio-MOFs); Drug Delivery; Bioactive Compounds; Food Sciences; Encapsulation; Bio-Molecule Separation; VITAMIN-A PALMITATE; BETA-CYCLODEXTRIN; POROUS MATERIALS; BIO-MOFS; ACID; STABILITY; LINKER; LIGANDS; DESIGN; DYE;

D O I：

10.1016/j.inoche.2024.113029

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Metal-organic frameworks (MOFs) and zeolitic imidazolate frameworks (ZIFs) have emerged as highly adaptable materials with a wide range of applications. Biological metal-organic frameworks (Bio-MOFs) enhance the compatibility with living organisms and the effectiveness of medications, nutraceuticals, and enzymes by increasing their stability, ability to be absorbed by the body, and solubility by utilizing naturally existing biomolecules as organic ligands. This review presents the latest developments in the encapsulation of bioactive compounds using Bio-MOFs. The review discusses the cytotoxicity of Bio-MOFs, their synthesis techniques, and activation processes. It also covers various applications such as drug delivery, food technology, molecular separation, biological sensing, cellular preservation, uremic toxin removal, gas separation, and the encapsulation of antioxidants and fragrances using cyclodextrin Bio-MOFs. The utilization of nucleobase adenine Bio-MOFs for the administration of anti-cancer drugs was thoroughly examined. Future perspectives include altering the release kinetics, elucidating the loading processes, and improving scalability.

引用

页数：14

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