A prognostic model constructed by ferroptosis-associated genes (FAGs) in papillary renal cell carcinoma (PRCC) and its association with tumor mutation burden (TMB) and immune infiltration

被引:1
作者
Chen, Yong-Bo [1 ]
Yang, Xin [2 ]
Lv, Dong [1 ]
Tang, Liang-You [1 ]
Liu, Ying-Wen [3 ]
机构
[1] Peoples Hosp Deyang City, Dept Urol, 173 Northern Taishan Rd, Deyang 618000, Peoples R China
[2] Peoples Hosp Deyang City, Dept Surg, 173 Northern Taishan Rd, Deyang 618000, Peoples R China
[3] Peoples Hosp Deyang City, Dept Lab, 173 Northern Taishan Rd, Deyang 618000, Peoples R China
关键词
FAGs; PRCC; Immune cell infiltration; TMB; MESSENGER-RNA; GLUTATHIONE; DEATH; DEGRADATION; PROTECTS; ENZYMES; LIVER;
D O I
10.1007/s12094-024-03617-y
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BackgroundThis study aimed to identify the prognostic-related differentially expressed ferroptosis-associated genes (DEFAGs) in papillary renal cell carcinoma (PRCC).MethodsData encompassing simple nucleotide variation, transcriptome profiles, and relevant clinical information of PRCC patients were sourced from The Cancer Genome Atlas (TCGA) database. The expression matrix of ferroptosis-associated genes (FAGs) was analyzed using the "limma" package in R to identify differentially expressed DEFAGs. Lasso regression analysis, along with univariate and multivariate Cox proportional hazards regressions, was employed to identify independent prognostic-related DEFAGs and formulate a nomogram. Additionally, we examined potential independent survival-related clinical risk factors and compared immune cell infiltration and tumor mutation burden (TMB) differences between high- and low-risk patient groups.ResultsA cohort of 321 patients were analyzed, revealing twelve FAGs significantly influencing the overall survival (OS) of PRCC patients. Among them, two mRNAs (GCLC, HSBP1) emerged as independent prognostic-related DEFAGs. Smoking status, tumor stage, and risk score were identified as independent clinical risk factors for PRCC. Furthermore, notable disparities in immune cell infiltration and function were observed between high- and low-risk groups. GCLC and HSBP1 were associated with various immune cells and functions, TMB, and immune evasion.ConclusionThis finding revealed two independent prognostic-related DEFAGs in PRCC and established a robust prognostic model, offering potential therapeutic targets and promising insights for the management of this disease.
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页码:1232 / 1247
页数:16
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