The Genetics of Human Sleep and Sleep Disorders

被引：2
作者：
Zou, Xianlin [1 ]
Ptacek, Louis J. [1 ,2 ,3 ,4 ]
Fu, Ying-Hui [1 ,2 ,3 ,4 ]
机构：
[1] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94115 USA
[2] Univ Calif San Francisco, Weill Inst Neurosci, San Francisco, CA USA
[3] Univ Calif San Francisco, Kavli Inst Fundamental Neurosci, San Francisco, CA USA
[4] Univ Calif San Francisco, Inst Human Genet, San Francisco, CA USA
来源：
ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS | 2024年 / 25卷
基金：
美国国家卫生研究院;
关键词：
human sleep genetics; sleep disorders; circadian rhythms; sleep homeostasis; genome-wide association studies; PHASE SYNDROME; LENGTH POLYMORPHISM; MUTATION; ASSOCIATION; NARCOLEPSY; VARIANTS; PHENOTYPE; RECEPTOR; PER3; HLA;
D O I：
10.1146/annurev-genom-121222-120306
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Healthy sleep is vital for humans to achieve optimal health and longevity. Poor sleep and sleep disorders are strongly associated with increased morbidity and mortality. However, the importance of good sleep continues to be underrecognized. Mechanisms regulating sleep and its functions in humans remain mostly unclear even after decades of dedicated research. Advancements in gene sequencing techniques and computational methodologies have paved the way for various genetic analysis approaches, which have provided some insights into human sleep genetics. This review summarizes our current knowledge of the genetic basis underlying human sleep traits and sleep disorders. We also highlight the use of animal models to validate genetic findings from human sleep studies and discuss potential molecular mechanisms and signaling pathways involved in the regulation of human sleep.
引用
收藏
页码：259 / 285
页数：27
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