SKF82958, a dopamine D1 receptor agonist, disrupts prepulse inhibition in the medial prefrontal cortex and nucleus accumbens in C57BL/6J mice

被引:1
作者
Yang, Chengmei [1 ,2 ]
Chen, Xiaoyu [1 ,2 ]
Xu, Jingyang [3 ]
Chen, Weihai [1 ,2 ]
机构
[1] Southwest Univ, Key Lab Cognit & Personal, Minist Educ, Chongqing, Peoples R China
[2] Southwest Univ, Fac Psychol, Chongqing, Peoples R China
[3] Southwest Univ, Westa Coll, Chongqing, Peoples R China
来源
BEHAVIOURAL PHARMACOLOGY | 2024年 / 35卷 / 04期
关键词
dopamine D1 receptor; prepulse inhibition; SCH23390; sensory gating; SKF82958; D2; RECEPTORS; SCHIZOPHRENIA; RAT; STARTLE;
D O I
10.1097/FBP.0000000000000768
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Prepulse inhibition (PPI) is a crucial indicator of sensorimotor gating that is often impaired in neuropsychiatric diseases. Although dopamine D1 receptor agonists have been found to disrupt PPI in mice, the underlying mechanisms are not fully understood. In this study, we aimed to identify the brain regions responsible for the PPI-disruptive effect of the D1 agonist in mice. Results demonstrated that intraperitoneal administration of the selective dopamine D1 receptor agonist SKF82958 dramatically inhibited PPI, while the dopamine D1 receptor antagonist SCH23390 enhanced PPI. Additionally, local infusion of SKF82958 into the nucleus accumbens and medial prefrontal cortex disrupted PPI, but not in the ventral hippocampus. Infusion of SCH23390 into these brain regions also failed to enhance PPI. Overall, the study suggests that the nucleus accumbens and medial prefrontal cortex are responsible for the PPI-disruptive effect of dopamine D1 receptor agonists. These findings provide essential insights into the cellular and neural circuit mechanisms underlying the disruptive effects of dopamine D1 receptor agonists on PPI and may contribute to the development of novel treatments for neuropsychiatric diseases.
引用
收藏
页码:193 / 200
页数:8
相关论文
共 24 条
[1]   Double dissociation between actions of dopamine D1 and D2 receptors of the ventral and dorsolateral striatum to produce reinstatement of cocaine seeking behavior [J].
Campos, Renan Costa ;
Dias, Carine ;
Darlot, Florence ;
Cador, Martine .
NEUROPHARMACOLOGY, 2020, 172
[2]   An Overview on the Search for Schizophrenia Biomarkers [J].
Cecilio Hallak, Jaime Eduardo ;
Damiao de Paula, Andre Luiz ;
Chaves, Cristiano ;
Bressan, Rodrigo Affonseca ;
Machado-de-Sousa, Joao Paulo .
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2015, 14 (08) :996-1000
[3]   Lifetime Prevalence and Correlates of Schizophrenia-Spectrum, Affective, and Other Non-affective Psychotic Disorders in the Chinese Adult Population [J].
Chang, Wing Chung ;
Wong, Corine Sau Man ;
Chen, Eric Yu Hai ;
Lam, Linda Chiu Wa ;
Chan, Wai Chi ;
Ng, Roger Man Kin ;
Hung, Se Fong ;
Cheung, Eric Fuk Chi ;
Sham, Pak Chung ;
Chiu, Helen Fung Kum ;
Lam, Ming ;
Lee, Edwin Ho Ming ;
Chiang, Tin Po ;
Chan, Lap Kei ;
Lau, Gary Kar Wai ;
Lee, Allen Ting Chun ;
Leung, Grace Tak Yu ;
Leung, Joey Shuk Yan ;
Lau, Joseph Tak Fai ;
van Os, Jim ;
Lewis, Glyn ;
Bebbington, Paul .
SCHIZOPHRENIA BULLETIN, 2017, 43 (06) :1280-1290
[4]   Effects of protein kinase A inhibitor and activator on rewarding effects of SKF-82958 microinjected into nucleus accumbens shell of ad libitum fed and food-restricted rats [J].
de Vaca, Soledad Cabeza ;
Peng, Xing-Xiang ;
Concors, Seth ;
Farin, Casey ;
Lascu, Elena ;
Carr, Kenneth D. .
PSYCHOPHARMACOLOGY, 2012, 221 (04) :589-599
[5]   Reward-representing D1-type neurons in the medial shell of the accumbens nucleus regulate palatable food intake [J].
Durst, Mate ;
Konczol, Katalin ;
Balazsa, Tamas ;
Eyre, Mark D. ;
Toth, Zsuzsanna E. .
INTERNATIONAL JOURNAL OF OBESITY, 2019, 43 (04) :917-927
[6]   Dopamine Modulates Adaptive Forgetting in Medial Prefrontal Cortex [J].
Gallo, Francisco Tomas ;
Saad, Maria Belen Zanoni ;
Silva, Azul ;
Morici, Juan Facundo ;
Miranda, Magdalena ;
Anderson, Michael C. ;
Weisstaub, Noelia, V ;
Bekinschtein, Pedro .
JOURNAL OF NEUROSCIENCE, 2022, 42 (34) :6620-6636
[7]   Prepulse Inhibition of the Auditory Startle Reflex Assessment as a Hallmark of Brainstem Sensorimotor Gating Mechanisms [J].
Gomez-Nieto, Ricardo ;
Hormigo, Sebastian ;
Lopez, Dolores E. .
BRAIN SCIENCES, 2020, 10 (09) :1-15
[8]   NNC-01-0687, A SELECTIVE DOPAMINE D1 RECEPTOR ANTAGONIST, IN THE TREATMENT OF SCHIZOPHRENIA [J].
KARLE, J ;
CLEMMESEN, L ;
HANSEN, L ;
ANDERSEN, M ;
ANDERSEN, J ;
FENSBO, C ;
SLOTHNIELSEN, M ;
SKRUMSAGER, BK ;
LUBLIN, H ;
GERLACH, J .
PSYCHOPHARMACOLOGY, 1995, 121 (03) :328-329
[9]   Dopamine, psychosis and schizophrenia: the widening gap between basic and clinical neuroscience [J].
Kesby, J. P. ;
Eyles, D. W. ;
McGrath, J. J. ;
Scott, J. G. .
TRANSLATIONAL PSYCHIATRY, 2018, 8
[10]   Mapping Brain Regions in Which Deep Brain Stimulation Affects Schizophrenia-Like Behavior in Two Rat Models of Schizophrenia [J].
Klein, Julia ;
Hadar, Ravit ;
Goetz, Thomas ;
Maenner, Anika ;
Eberhardt, Claudia ;
Baldassarri, Jacopo ;
Schmidt, Timo Torsten ;
Kupsch, Andreas ;
Heinz, Andreas ;
Morgenstern, Rudolf ;
Schneider, Miriam ;
Weiner, Ina ;
Winter, Christine .
BRAIN STIMULATION, 2013, 6 (04) :490-499