Update on the genetic profile of mitral valve development and prolapse

被引：3

作者：

Opris, Carmen Elena ^{[1
,2
,5
]}

Suciu, Horatiu ^{[3
,4
,5
]}

Flamand, Sanziana ^{[3
,5
]}

Opris, Cosmin Ioan ^{[3
,5
]}

Hamida, Al Hussein ^{[3
]}

Gurzu, Simona ^{[2
,4
,6
]}

机构：

[1] Emergency Inst Cardiovasc Dis & Transplantat, Dept Adult & Children Cardiovasc Recovery, Targu Mures 540139, Romania

[2] George Emil Palade Univ Med Pharm Sci & Technol, Dept Pathol, 38 Gheorghe Marinescu St, Targu Mures 540139, Romania

[3] George Emil Palade Univ Med Pharm Sci & Technol, Dept Surg, Targu Mures 540139, Romania

[4] Romanian Acad Med Sci, Bucharest, Romania

[5] Emergency Cty Hosp, Dept Cardiovasc Surg, Bucharest, Romania

[6] George Emil Palade Univ Med Pharm Sci & Technol, Res Ctr Oncopathol & Translat Med CCOMT, Targu Mures, Romania

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2024年 / 262卷

关键词：

Mitral valve prolapse; Embryology; Genes; DEVELOPING HEART-VALVES; MESENCHYMAL TRANSITION; MATRIX METALLOPROTEINASES; TISSUE INHIBITORS; MUTATIONS; VARIANTS; CRELD1;

D O I：

10.1016/j.prp.2024.155535

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The purpose of this review is to present a comprehensive overview of the literature published up to February 2024 on the PubMed database regarding the development of mitral valve disease, with detailed reference to mitral valve prolapse, from embryology to a genetic profile. Out of the 3291 publications that deal with mitral valve embryology, 215 refer to mitral valve genetics and 83 were selected for further analysis. After reviewing these data, we advocate for the importance of a gene-based therapy that should be available soon, to prevent or treat non-invasively the valvular degeneration.

引用

页数：7

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