Late-onset vitamin K deficiency presenting as haemorrhagic shock and severe multi-system organ failure

被引:0
|
作者
Azar, Justin M. [1 ,2 ]
Lambert, Richard [1 ,2 ]
Maffei, Frank Anthony [1 ,2 ]
Thomas, Tessy A. [1 ,2 ]
机构
[1] Janet Weis Childrens Hosp, Danville, PA 17822 USA
[2] Geisinger Commonwealth Sch Med, Pediat, Scranton, PA 18509 USA
关键词
Preventative pediatrics; Neonatal and paediatric intensive care; Routine care of the full-time infant; Infant health; Haematology (incl blood transfusion); INTRACRANIAL HEMORRHAGE; THYMIC HEMORRHAGE; INFANTS; DISEASE;
D O I
10.1136/bcr-2024-261126
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Vitamin K is an essential dietary cofactor required for the synthesis of active forms of vitamin K-dependent procoagulant proteins. Vitamin K deficiency, particularly late-onset deficiency occurring between 1 week and 6 months of age, can cause a life-threatening bleeding disorder. An exclusively breastfed, full-term, 6-week-old infant male presented with severe haemorrhagic shock and multi-system organ failure related to caregiver refusal of intramuscular vitamin K after birth. Coagulation studies were normalised within 8 hours of intramuscular vitamin K administration. An increasing number of caregivers are refusing intramuscular vitamin K which has led to a rise in the incidence of vitamin K deficiency bleeding. Health policy organisations around the world emphasise the benefits of intramuscular vitamin K and risks of refusal, particularly in exclusively breastfed infants who are at higher risk due to low vitamin K levels in breast milk. This case highlights the multi-system severity of this life-threatening yet preventable disorder.
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页码:1 / 4
页数:4
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