Sleep to Upscale, Sleep to Downscale: Balancing Homeostasis and Plasticity

被引：52

作者：

Born, Jan ^{[1
]}

Feld, Gordon B. ^{[1
]}

机构：

[1] Univ Tubingen, Dept Med Psychol & Behav Neurobiol, D-72076 Tubingen, Germany

来源：

NEURON | 2012年 / 75卷 / 06期

关键词：

SYNAPTIC HOMEOSTASIS; MEMORY; HYPOTHESIS; CORTEX; WAKE;

D O I：

10.1016/j.neuron.2012.09.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The synaptic homeostasis hypothesis of sleep proposes that slow wave sleep (SWS) causes downscaling of synaptic networks potentiated during information uptake in prior wakefulness. Two studies in Neuron challenge this mechanism. Chauvette et al. (2012) show that SWS mediates an up-rather than downregulation of excitatory postsynaptic potential responses. Grosmark et al. (2012) find that downscaling in hippocampal networks might be mediated through REM sleep theta rather than SWS.

引用

页码：933 / 935

页数：3

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