Dual effects of dulaglutide on glycemic control and knee osteoarthritis pain in elderly patients with Type 2 diabetes

Aim: This study aims to evaluate the dual benefits of dulaglutide in improving glycemic control and reducing knee OA pain. Patients & methods: Elderly T2DM patients diagnosed with bilateral knee OA on conventional OA treatment for at least 3 months were studied for their glycemic metrics, OA pain scores and NSAID consumption at baseline, 3 months and 6 months. Results: Significant improvements in glycemic control were observed, HbA1c decreased from 8.7% to 6.5% over 6 months. Pain scores, NSAID, body weight and BMI showed substantial reductions over time. Positive correlation (r = 0.73, p < 0.001) was found between glycemic control and pain reduction. Conclusion: Dulaglutide improves glycemic control, knee joint OA pain and weight management in elderly patients with T2DM. Plain Language Summary What is this article about?: We looked into how well dulaglutide works to both control blood sugar and reduce knee pain in people with type 2 Diabetes and osteoarthritis. This could be a useful treatment for older patients dealing with both conditions. What were the results?: The most relevant findings were: center dot Better Blood Sugar Control: After using dulaglutide for three and 6 months, there were noticeable improvements in blood sugar levels. center dot Less Knee Pain: People experienced less knee pain from osteoarthritis and used fewer painkillers. center dot Weight Loss: The average body weight and body mass index (BMI) decreased with this treatment. center dot Pain Relief Linked to Better Blood Sugar: As blood sugar levels improved, knee pain from osteoarthritis also lessened. What do the results of the study mean?: The results showed that elderly T2DM patients prescribed with dulaglutide would be able to achieve improved glycemic control, knee joint OA pain and weight management.