Desire for pregnancy and fertility preservation in young patients with breast cancer

被引:0
作者
Abe, Tomomi [1 ]
Kataoka, Akemi [1 ]
Uehiro, Natsue [1 ]
Yoshida, Nao [1 ]
Nishimura, Meiko [2 ]
Ozaki, Yukinori [2 ]
Kogawa, Takahiro [3 ]
Takano, Toshimi [2 ]
Ohno, Shinji [4 ]
Ueno, Takayuki [1 ]
机构
[1] Japanese Fdn Canc Res, Canc Inst Hosp, Breast Oncol Ctr, Dept Breast Surg Oncol, 3-8-31 Ariake,Koutou Ku, Tokyo 1358550, Japan
[2] Japanese Fdn Canc Res, Canc Inst Hosp, Breast Oncol Ctr, Dept Breast Med Oncol, 3-8-31 Ariake,Koutou Ku, Tokyo 1358550, Japan
[3] Japanese Fdn Canc Res, Dept Adv Med Dev Ctr, Canc Inst Hosp, 3-8-31 Ariake,Koutou Ku, Tokyo 1358550, Japan
[4] Japanese Fdn Canc Res, Canc Inst Hosp, Breast Oncol Ctr, 3-8-31 Ariake,Koutou Ku, Tokyo 1358550, Japan
关键词
Breast cancer; Desire for pregnancy; Fertility preservation; Young patients; WOMEN;
D O I
10.1007/s12282-024-01633-y
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background Data on the desire for pregnancy and the status of fertility preservation (FP) in patients with breast cancer remain unclear. This study aimed to determine the status of patients with breast cancer who desired pregnancy and FP implementation before systemic therapy. Methods This retrospective study surveyed the institutional clinical databases and electronic medical records of patients aged < 43 years with stages 0-III primary breast cancer during surgery and treated between April 2020 and March 2021. All patients were enquired about their desire for pregnancy in a questionnaire by "present," "absent," and "unsure" at their first visit. The correlation between the desire for pregnancy, implementation of FP, and clinicopathological factors was investigated. Results Among 1005 patients who underwent surgery for primary breast cancer, 146 were included in the analysis. Of them, 34 (23.3%) patients had a desire for pregnancy, and 45 (30.8%) chose "unsure." Factors associated with the desire for pregnancy were younger age during surgery (p < 0.0022), unmarried status (p < 0.001), nulliparity (p < 0.001), early-stage disease (p = 0.0016), and estrogen receptor positivity (p = 0.008). Among 115 patients who underwent systemic therapy, 13 (11.3%) underwent FP before systemic therapy. Patients who were nulliparous frequently pursued FP (p = 0.0195). The proportion of FP implementation was low in patients who received neoadjuvant chemotherapy (p = 0.0863). Conclusions Our study suggests that unmarried, nulliparous, and younger patients were more interested in pregnancy, and nulliparous patients frequently pursued FP.
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收藏
页码:1137 / 1143
页数:7
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