Renoprotective Effects of Daprodustat in Patients with Chronic Kidney Disease and Renal Anemia

被引：0

作者：

Shimada, Yoshitaka ^{[1
]}

Izumi, Yuichiro ^{[2
]}

Yasuoka, Yukiko ^{[3
]}

Oshima, Tomomi ^{[3
]}

Nagaba, Yasushi ^{[1
]}

Nanami, Masayoshi ^{[4
]}

Sands, Jeff M. ^{[5
]}

Takahashi, Noriko ^{[3
]}

Kawahara, Katsumasa ^{[3
]}

Nonoguchi, Hiroshi ^{[1
,6
]}

机构：

[1] Kitasato Univ, Med Ctr, Div Internal Med, 6-100 Arai, Kitamoto, Saitama 3648501, Japan

[2] Kumamoto Univ, Dept Nephrol, Grad Sch Med Sci, 1-1-1 Honjo,Chuo Ku, Kumamoto, Kumamoto 8608556, Japan

[3] Kitasato Univ, Dept Physiol, Sch Med, 1-15-1 Kitasato,Minami Ku, Sagamihara, Kanagawa 2520374, Japan

[4] Hyogo Med Univ, Dept Cardiovasc & Renal Med, 1-1 Mukogawa Cho, Nishinomiya, Hyogo 6638501, Japan

[5] Emory Univ, Dept Med, Renal Div, Sch Med, 1639 Pierce Dr, WMB Room 1107, Atlanta, GA 30322 USA

[6] Sagamihara Red Cross Hosp, Nephrol Internal Med, 256 Nakano,Midori Ku, Sagamihara, Kanagawa 2520157, Japan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 17期

关键词：

erythropoietin; PHD inhibitor; hypoxia; deglycosylation; proximal tubules; distal tubules; renal erythropoietin-producing interstitial cells; ERYTHROPOIETIN REGULATION;

D O I：

10.3390/ijms25179468

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Many large-scale studies revealed that exogenous erythropoietin, erythropoiesis-stimulating agents, have no renoprotective effects. We reported the renoprotective effects of endogenous erythropoietin production on renal function in ischemic reperfusion injury (IRI) of the kidney using the prolyl hydroxylase domain (PHD) inhibitor, Roxadustat. The purpose of this study was to investigate the effects of daprodustat on the progression of chronic renal failure. We retrospectively investigated the effects of daprodustat on the progression of chronic renal failure and renal anemia in patients with stages 3a-5 chronic kidney diseases (estimated glomerular filtration rate, eGFR < 60 mL/min/1.73 m(2)). The results show that daprodustat largely slowed the reduction in eGFR. The recovery of renal function was observed in some patients. Daprodustat is useful not only for renal anemia but also for the preservation of renal function. The renoprotective effect of daprodustat was small in patients with serum creatinine larger than 3-4 mg/dL because of low residual renal function. The appearance of renal anemia would be a sign of the time to start using daprodustat.

引用

页数：10

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