Effect of Degradation and Osteoarthritis on the Viscoelastic Properties of Human Knee Articular Cartilage: An Experimental Study and Constitutive Modeling

被引:3
作者
Khajehsaeid, Hesam [1 ,2 ]
Abdollahpour, Zanko [2 ]
Farahmandpour, Hedyeh [2 ]
机构
[1] Univ Warwick, WMG, Coventry CV4 7AL, England
[2] Univ Tabriz, Sch Engn, Tabriz 5166616471, Iran
来源
BIOMECHANICS | 2021年 / 1卷 / 02期
关键词
articular cartilage; degradation; osteoarthritis; viscoelasticity; fractional-order model; UNCONFINED COMPRESSION; MECHANICAL-PROPERTIES; STRESS-RELAXATION; COLLAGEN NETWORK; BEHAVIOR; RUBBER; DERIVATIVES; RESPONSES; TENSILE; JOINTS;
D O I
10.3390/biomechanics1020019
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Articular cartilage, as a hydrated soft tissue which covers diarthrodial joints, has a pivotal role in the musculoskeletal system. Osteoarthritis is the most common degenerative disease that affects most individuals over the age of 55. This disease affects the elasticity, lubrication mechanism, damping function, and energy absorption capability of articular cartilage. In order to investigate the effect of osteoarthritis on the performance of articular cartilage, the mechanical behavior of human knee articular cartilage was experimentally investigated. Progressive cyclic deformation was applied beyond the physiological range to facilitate degradation of the tissue. The relaxation response of the damaged tissue was modeled by means of a fractional-order nonlinear viscoelastic model in the framework of finite deformations. It is shown that the proposed fractional model well reproduces the tissue's mechanical behavior using a low number of parameters. Alteration of the model parameters was also investigated throughout the progression of tissue damage. This helps predict the mechanical behavior of the osteoarthritic tissue based on the level of previous damage. It is concluded that, with progression of osteoarthritis, the articular cartilage loses its viscoelastic properties such as damping and energy absorption capacity. This is also accompanied by a loss of stiffness which deteriorates more rapidly than viscosity does throughout the evolution of tissue damage. These results are thought to be significant in better understanding the degradation of articular cartilage and the progression of OA, as well as in the design of artificial articular cartilages.
引用
收藏
页码:225 / 238
页数:14
相关论文
共 50 条
  • [31] Importance of Material Properties and Porosity of Bone on Mechanical Response of Articular Cartilage in Human Knee Joint-A Two-Dimensional Finite Element Study
    Venalainen, Mikko S.
    Mononen, Mika E.
    Jurvelin, Jukka S.
    Toyras, Juha
    Viren, Tuomas
    Korhonen, Rami K.
    JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 2014, 136 (12):
  • [32] Viscoelastic properties of human and bovine articular cartilage: a comparison of frequency-dependent trends
    Duncan K. Temple
    Anna A. Cederlund
    Bernard M. Lawless
    Richard M. Aspden
    Daniel M. Espino
    BMC Musculoskeletal Disorders, 17
  • [33] Histone Extraction from Human Articular Cartilage for the Study of Epigenetic Regulation in Osteoarthritis
    Nunez-Carro, Carmen
    Blanco-Blanco, Margarita
    Montoya, Tatiana
    Villagran-Andrade, Karla M.
    Hermida-Gomez, Tamara
    Blanco, Francisco J.
    de Andres, Maria C.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (06)
  • [34] Histological study of articular cartilage in experimental rat knee arthritis induced by intracapsular injection of cationic polyethyleneimine
    Sakano Y.
    Terada N.
    Ueda H.
    Fujii Y.
    Hamada Y.
    Akamatsu N.
    Ohno S.
    Medical Electron Microscopy, 2000, 33 (4): : 246 - 257
  • [35] Experimental and constitutive modeling approaches for a study of biomechanical properties of human coronary arteries
    Jankowska, Malgorzata A.
    Bartkowiak-Jowsa, Magdalena
    Bedzinski, Romuald
    JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, 2015, 50 : 1 - 12
  • [36] Raman spectroscopy investigation of load-assisted microstructural alterations in human knee cartilage: Preliminary study into diagnostic potential for osteoarthritis
    Takahashi, Yasuhito
    Sugano, Nobuhiko
    Takao, Masaki
    Sakai, Takashi
    Nishii, Takashi
    Pezzotti, Giuseppe
    JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, 2014, 31 : 77 - 85
  • [37] The effect of water content on biomechanical behavior of articular cartilage: An experimental study
    Abd Latif, Mohd Juzaila
    Ru, Yew Sin
    Zakaria, Mohamad Shukri
    PROCEEDINGS OF MECHANICAL ENGINEERING RESEARCH DAY 2019 (MERD'19), 2019, : 91 - 92
  • [38] Effect of the presence of the articular cartilage on the femoral component rotation in total knee arthroplasty in female and varus osteoarthritis knees
    Ji-Hoon Nam
    Yong-Gon Koh
    Paul Shinil Kim
    Joon-Hee Park
    Kyoung-Tak Kang
    Journal of Orthopaedic Surgery and Research, 15
  • [39] Effect of the presence of the articular cartilage on the femoral component rotation in total knee arthroplasty in female and varus osteoarthritis knees
    Nam, Ji-Hoon
    Koh, Yong-Gon
    Kim, Paul Shinil
    Park, Joon-Hee
    Kang, Kyoung-Tak
    JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH, 2020, 15 (01)
  • [40] Longitudinal study of sodium MRI of articular cartilage in patients with knee osteoarthritis: initial experience with 16-month follow-up
    Madelin, Guillaume
    Xia, Ding
    Brown, Ryan
    Babb, James
    Chang, Gregory
    Krasnokutsky, Svetlana
    Regatte, Ravinder R.
    EUROPEAN RADIOLOGY, 2018, 28 (01) : 133 - 142