Use of Cefiderocol in the Management of Children With Infection or Colonization With Multi-drug Resistant Gram-negative Bacteria: A Retrospective, Single-center Case Series

被引：1

作者：

Schmid, Hanna ^{[1
]}

Brown, Li-An K. ^{[2
]}

Indrakumar, Bairavi ^{[3
]}

McGarrity, Orlagh ^{[3
]}

Hatcher, James ^{[2
]}

Bamford, Alasdair ^{[1
,4
]}

机构：

[1] Great Ormond St Hosp Children NHS Fdn Trust, Paediat Infect Dis, Great Ormond St, London WC1N 3JH, England

[2] Great Ormond St Hosp Children NHS Fdn Trust, Dept Microbiol, Lab Med, London, England

[3] Great Ormond St Hosp Children NHS Fdn Trust, Pharm Dept, London, England

[4] UCL Great Ormond St Inst Child Hlth, Infect Immun & Inflammat Dept, London, England

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2024年 / 43卷 / 08期

关键词：

antimicrobial resistance; cefiderocol; multidrug-resistant Gram-negative bacteria; novel antimicrobials; pediatric;

D O I：

10.1097/INF.0000000000004347

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cefiderocol, a novel siderophore cephalosporin, represents a treatment option for infections with multidrug-resistant Gram-negative bacteria, of which rates are rising worldwide. Clinical data on its use in children is limited. In our pediatric case series, the largest reported to date, cefiderocol seems safe and well tolerated, with more favorable clinical outcomes when compared to the literature reviewing adult cases.

引用

页码：772 / 776

页数：5

共 12 条

[11] Infectious Diseases Society of America 2023 Guidance on the Treatment of Antimicrobial Resistant Gram-Negative Infections
Tamma, Pranita D.
Aitken, Samuel L.
Bonomo, Robert A.
Mathers, Amy J.
van Duin, David
Clancy, Cornelius J.
[J]. CLINICAL INFECTIOUS DISEASES, 2023,
[12] Cefiderocol versus high-dose, extended-infusion meropenem for the treatment of Gram-negative nosocomial pneumonia (APEKS-NP): a randomised, double-blind, phase 3, non-inferiority trial
Wunderink, Richard G.
Matsunaga, Yuko
Ariyasu, Mari
Clevenbergh, Philippe
Echols, Roger
Kaye, Keith S.
Kollef, Marin
Menon, Anju
Pogue, Jason M.
Shorr, Andrew F.
Timsit, Jean-Francois
Zeitlinger, Markus
Nagata, Tsutae D.
[J]. LANCET INFECTIOUS DISEASES, 2021, 21 (02) : 213 - 225

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