Asymmetric Auto-Tandem Catalysis with Chiral Organosuperbases: Intramolecular Cyclization/Enantioselective Direct Mannich-Type Addition Sequence

被引：3

作者：

Kondoh, Azusa ^{[1
]}

Kato, Takuro ^{[2
]}

Chen, Hao ^{[2
]}

Terada, Masahiro ^{[2
]}

机构：

[1] Tohoku Univ, Res & Analyt Ctr Giant Mol, Grad Sch Sci, Sendai 9808578, Japan

[2] Tohoku Univ, Grad Sch Sci, Dept Chem, Sendai 9808578, Japan

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 30期

关键词：

D O I：

10.1021/acs.orglett.4c02532

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An enantioselective addition reaction of alkynyl esters with imines was developed under asymmetric autotandem catalysis with a chiral Br & oslash;nsted base. A chiral bis(guanidino)iminophosphorane organosuperbase, which has much higher basicity than that of conventional chiral organic bases, efficiently promoted both the intramolecular cyclization for the construction of a benzofuran ring or a benzothiophene ring and the sequential enantioselective direct Mannich-type reaction of diarylmethane derivatives, affording enantio-enriched diarylalkane derivatives that are otherwise difficult to access.

引用

页码：6523 / 6528

页数：6

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