Influence fl uence of Diclofenac Potassium versus Prednisolone on Postendodontic Pain and Pulpal Interleukin-8 Expression in Symptomatic Irreversible Pulpitis Cases: A Randomized Placebo-controlled Trial

被引:1
|
作者
Soliman, Ahmed Adel [1 ,2 ]
Ezzat, Khaled Mohamed [1 ]
Shaker, Olfat Gamil [3 ]
Abouelenien, Sarah Samir [1 ]
机构
[1] Cairo Univ, Fac Dent, Endodont Dept, Cairo, Egypt
[2] Newgiza Univ, Sch Dent, Cairo, Egypt
[3] Cairo Univ, Fac Med, Med Biochem & Mol Biol Dept, Cairo, Egypt
关键词
Cytokine expression; inflammatory markers; interleukin-8; irreversible pulpitis; ROOT-CANAL TREATMENT; POSTOPERATIVE PAIN; ANALGESIC EFFICACY; PREMEDICATION; PREVALENCE; CYTOKINES; MEDIATORS; IBUPROFEN; SYSTEMS; MOLARS;
D O I
10.1016/j.joen.2024.05.019
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Aim: This prospective, randomized, double-blind clinical trial investigated the impact of diclofenac potassium, prednisolone, and placebo as oral premedication on postendodontic pain and pulpal interleukin (IL)-8 expression in patients with irreversible pulpitis. Methods: Thirty-six patients undergoing conventional endodontic treatment were assigned into one of 3 groups (n = 12). Pulpal blood samples were taken after access cavity preparation and stored until they were analyzed using enzyme-linked immunosorbent asssay for quantification of IL-8. Postendodontic pain was scored using the visual analogue scale. Outcome data were statistically analyzed using one-way analysis of variance, Kruskal-Wallis, Friedman's, Dunn's, Chi-square, and Fisher's exact tests and Spearman's correlation coefficient. The significance level (alpha) was set at 0.05. Results: Apart from preoperative pain scores, all groups had similar baseline characteristics (P > .05). Immediate postendodontic pain scores had a significant difference between all groups (P < .05) where placebo group showed the highest score. There was no significant difference between all groups at 6 and 12 hours postoperatively (P > .05). Furthermore, there was no significant difference in the incidence of postendodontic pain and in mean IL-8 levels between the 3 groups (P > .05). Conclusions: The only impact the premedications had was on the immediate postendodontic pain intensity, and they had no influence on the later time points, incidence of postendodontic pain or pulpal IL-8 levels.
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页码:1213 / 1220
页数:8
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