mRNA Localization and Translational Control in Drosophila Oogenesis

被引：71
作者：
Lasko, Paul [1 ]
机构：
[1] McGill Univ, Dept Biol, Montreal, PQ H3G 0B1, Canada
来源：
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2012年 / 4卷 / 10期
关键词：
TO-ZYGOTIC TRANSITION; EMBRYONIC AXIS SPECIFICATION; BICOID MORPHOGEN GRADIENT; STEM-CELL DIFFERENTIATION; BINDING-PROTEIN; ANTERIOR-POSTERIOR; OSKAR TRANSLATION; NANOS TRANSLATION; GERM PLASM; CYTOPLASMIC POLYADENYLATION;
D O I：
10.1101/cshperspect.a012294
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Localization of an mRNA species to a particular subcellular region can complement translational control mechanisms to produce a restricted spatial distribution of the protein it encodes. mRNA localization has been studied most in asymmetric cells such as budding yeast, early embryos, and neurons, but the process is likely to be more widespread. This article reviews the current state of knowledge about the mechanisms of mRNA localization and its functions in early embryonic development, focusing on Drosophila where the relevant knowledge is most advanced. Links between mRNA localization and translational control mechanisms also are examined.
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页数：15
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