Targeting senescent cells in aging and COVID-19: from cellular mechanisms to therapeutic opportunities

被引：1
作者：
Yu, Yuan [1 ,2 ]
Lin, Kaixuan [1 ]
Wu, Haoyu [1 ]
Hu, Mingli [1 ,3 ]
Yang, Xuejie [1 ]
Wang, Jie [1 ]
Grillari, Johannes [4 ,5 ,6 ]
Chen, Jiekai [1 ]
机构：
[1] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangdong Prov Key Lab Stem Cell & Regenerat Med, Ctr Cell Lineage & Atlas,Guangdong Hong Kong Joint, Guangzhou 510530, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[3] Guangzhou Univ Chinese Med, Sci & Technol Innovat Ctr, Guangzhou 510405, Peoples R China
[4] Austrian Cluster Tissue Regenerat, Vienna, Austria
[5] BOKU Univ, Inst Mol Biotechnol, Vienna, Austria
[6] AUVA, Res Ctr Cooperat, Ludwig Boltzmann Inst Traumatol, A-1200 Vienna, Austria
来源：
CELL REGENERATION | 2024年 / 13卷 / 01期
关键词：
COVID-19; Aging; Cellular Senescence; Anti-aging Therapies; LIFE-SPAN; INFLAMMATION; DIFFERENTIATION; REGENERATION; INHIBITORS; PHYSIOLOGY; REGULATOR; MTOR;
D O I：
10.1186/s13619-024-00201-1
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
The COVID-19 pandemic has caused a global health crisis and significant social economic burden. While most individuals experience mild or non-specific symptoms, elderly individuals are at a higher risk of developing severe symptoms and life-threatening complications. Exploring the key factors associated with clinical severity highlights that key characteristics of aging, such as cellular senescence, immune dysregulation, metabolic alterations, and impaired regenerative potential, contribute to disruption of tissue homeostasis of the lung and worse clinical outcome. Senolytic and senomorphic drugs, which are anti-aging treatments designed to eliminate senescent cells or decrease the associated phenotypes, have shown promise in alleviating age-related dysfunctions and offer a novel approach to treating diseases that share certain aspects of underlying mechanisms with aging, including COVID-19. This review summarizes the current understanding of aging in COVID-19 progression, and highlights recent findings on anti-aging drugs that could be repurposed for COVID-19 treatment to complement existing therapies.
引用
收藏
页数：13
相关论文
共 105 条
[1]   Confirmed Coronavirus Disease-19 (COVID-19) in a Male with Chronic Myeloid Leukemia Complicated by Febrile Neutropenia and Acute Respiratory Distress Syndrome [J].
Abdalhadi, Ahmed M. ;
Alshurafa, Awni ;
Alkhatib, Mohammed ;
Abou Kamar, Mohamed ;
Yassin, Mohamed A. .
CASE REPORTS IN ONCOLOGY, 2020, 13 (02) :569-577
[2]   SARS-CoV-2 (COVID-19) and Chronic Myeloid Leukemia (CML): a Case Report and Review of ABL Kinase Involvement in Viral Infection [J].
Abruzzese, Elisabetta ;
Luciano, Luigiana ;
D'Agostino, Francesco ;
Trawinska, Malgorzata Monika ;
Pane, Fabrizio ;
De Fabritiis, Paolo .
MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES, 2020, 12
[3]   Quercetin: Antiviral Significance and Possible COVID-19 Integrative Considerations [J].
Agrawal, Pawan K. ;
Agrawal, Chandan ;
Blunden, Gerald .
NATURAL PRODUCT COMMUNICATIONS, 2020, 15 (12)
[4]   Distinct Spatiotemporally Dynamic Wnt-Secreting Niches Regulate Proximal Airway Regeneration and Aging [J].
Aros, Cody J. ;
Vijayaraj, Preethi ;
Pantoja, Carla J. ;
Bisht, Bharti ;
Meneses, Luisa K. ;
Sandlin, Jenna M. ;
Tse, Jonathan A. ;
Chen, Michelle W. ;
Purkayastha, Arunima ;
Shia, David W. ;
Sucre, Jennifer Ms ;
Rickabaugh, Tammy M. ;
Vladar, Eszter K. ;
Paul, Manash K. ;
Gomperts, Brigitte N. .
CELL STEM CELL, 2020, 27 (03) :413-+
[5]   BCR-ABL Tyrosine Kinase Inhibitors as Candidates for the Treatment of COVID-19: Molecular Docking, Pharmacophore Modeling, ADMET Studies [J].
Attia, Mohamed S. ;
Hassaballah, Mohammed Y. ;
Negida, Ahmed ;
Sebaiy, Mahmoud M. ;
Ziedan, Noha, I .
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY, 2022, 12 (03) :3357-3371
[6]   The triumvirate of NF-ΚB, inflammation and cytokine storm in COVID-19 [J].
Attiq, Ali ;
Yao, Lui Jin ;
Afzal, Sheryar ;
Khan, Mansoor Ali .
INTERNATIONAL IMMUNOPHARMACOLOGY, 2021, 101
[7]   Musculoskeletal symptoms in patients with long COVID: A cross-sectional study on Iranian patients [J].
Azadvari, Mohaddeseh ;
Haghparast, Afarin ;
Nakhostin-Ansari, Amin ;
Razavi, Seyede Zahra Emami ;
Hosseini, Maryam .
HELIYON, 2022, 8 (08)
[8]   Aging, Immunity, and COVID-19: How Age Influences the Host Immune Response to Coronavirus Infections? [J].
Bajaj, Varnica ;
Gadi, Nirupa ;
Spihlman, Allison P. ;
Wu, Samantha C. ;
Choi, Christopher H. ;
Moulton, Vaishali R. .
FRONTIERS IN PHYSIOLOGY, 2021, 11
[9]   Angiotensin-converting enzyme 2 (ACE2) expression increases with age in patients requiring mechanical ventilation [J].
Baker, Steven Andrew ;
Kwok, Shirley ;
Berry, Gerald J. ;
Montine, Thomas J. .
PLOS ONE, 2021, 16 (02)
[10]   Persistence of somatic symptoms after COVID-19 in the Netherlands: an observational cohort study [J].
Ballering, Aranka, V ;
van Zon, Sander K. R. ;
Hartman, Tim Colde ;
Rosmalen, Judith G. M. ;
Lifelines Corona Res Initiative .
LANCET, 2022, 400 (10350) :452-461
12345678910